Immune response modifying activity in mice of polyinosinic: polycytidylic acid stabilized with poly-L-lysine, in carboxymethylcellulose [poly-ICLC

International Journal of Immunopharmacology
M A ChirigosH B Levy

Abstract

Poly-ICLC, a polyinosinic: polycytidylic acid stabilized with poly-L-lysine in carboxymethyl-cellulose was tested in mice for its immunoregulatory activity. Poly-ICLC was found to enhance T cell responsiveness but not B cells. It augmented the delayed type hypersensitivity response significantly. The results indicate Poly-ICLC to be a T cell stimulator. Macrophage tumoricidal activity was markedly enhanced both in vitro and in vivo after exposure to Poly-ICLC. Natural killer cell cytotoxicity was significantly augmented in vivo. Both macrophage and natural killer cell activity was maintained for over 3 days after only one treatment. The extended period of tumor cell cytotoxicity, exhibited by macrophages and natural killer cells, may correlate to Poly-ICLC induction of early and high levels of interferon which are maintained in the serum for a longer period of time.

References

Apr 1, 1979·Cellular Immunology·A SenikH Wigzell
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·A SantoniE Bonmassar
Jan 1, 1979·International Archives of Allergy and Applied Immunology·A M Attallah, T Folks
Oct 1, 1975·The Journal of Infectious Diseases·H B LevyJ Rice
Aug 12, 1977·Science·R M SchultzM A Chirigos
Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·A F WoodhourM R Hilleman
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A K FieldM R Hilleman
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·L W Catalano, S Baron
Feb 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J J NordlundH B Levy
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·C E BucklerS Baron

❮ Previous
Next ❯

Citations

Jan 1, 1985·Springer Seminars in Immunopathology·J E Talmadge, M A Chirigos
Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K SoneharaT Tokunaga
Aug 1, 1984·Cellular Immunology·T P KoestlerG Poste
Jan 1, 1987·Annals of the New York Academy of Sciences·R KirshG Poste

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2021 Meta ULC. All rights reserved