PMID: 8944364Nov 1, 1996Paper

Immune response to Clostridium difficile infection

European Journal of Gastroenterology & Hepatology
C P Kelly

Abstract

Clostridium difficile produces two toxins (A and B) which cause antibiotic-associated diarrhoea and pseudomembranous colitis. One of the most puzzling aspects of C. difficile infection is the wide spectrum of clinical presentation which ranges from asymptomatic carriage to fulminant, life-threatening colitis. This review examines the hypothesis that immune responses to C. difficile underlie these dramatic variations in disease presentation and course. Animals can be protected from C. difficile colitis by passive or active immunization against toxins A and B. Human antibody responses to these toxins are evident in approximately 60% of the general population. A number of clinical studies indicate that antitoxin responses in both serum and intestinal secretions may be protective whereas an inadequate immune response predisposes to severe or recurrent C. difficile diarrhoea. Thus there is now considerable interest in developing methods for passive and active immunization to combat this prevalent nosocomial intestinal pathogen.

Citations

May 11, 2010·Techniques in Coloproctology·B FarisN Haboubi
Apr 5, 2001·Current Infectious Disease Reports·William P. Ciesla, David A. Bobak
May 20, 2004·Current Treatment Options in Gastroenterology·John R. Stroehlein
Feb 10, 2000·The New England Journal of Medicine·L KyneC P Kelly
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques PépinLuc Lanthier
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alex CarignanLouis Valiquette
Jun 30, 2010·Surgical Infections·Andrea D OlivasJohn C Alverdy
Mar 25, 2009·Infection and Immunity·Xiangyun HeHanping Feng
Feb 22, 2003·Infection and Immunity·Samer AboudolaCiarán P Kelly
Mar 24, 1998·Annual Review of Medicine·C P Kelly, J T LaMont
May 11, 2013·Current Medical Research and Opinion·Chaitanya PantThomas J Sferra
Jul 7, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E BouzaR Alonso
Jun 2, 2010·Clinics in Laboratory Medicine·Scott Curry
Jul 5, 2007·The American Journal of Geriatric Pharmacotherapy·Ali Hassoun, Farrah Ibrahim
Jul 20, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Z F GelladA J Muir
Mar 4, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C C GundersonV G Valentine
Jun 22, 2010·Pediatric Transplantation·J B RosenO Elidemir
Jun 29, 2011·FEMS Immunology and Medical Microbiology·Séverine PéchinéAnne Collignon
Nov 18, 2015·BMC Infectious Diseases·Luis Furuya-KanamoriArchie C A Clements
Jul 22, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Denise DrudyLorraine Kyne
Jun 16, 2004·FEMS Immunology and Medical Microbiology·Denise DrudyCiarán P Kelly
Dec 26, 2009·Journal of Intensive Care Medicine·Marc-André LeclairJacques Pépin
Feb 4, 2016·Emerging Microbes & Infections·Chandrabali GhoseDavid D Ho
Apr 14, 1999·The American Journal of Gastroenterology·S Meyers
Oct 16, 2008·The American Journal of Gastroenterology·M Raffat JaberMark E Reeves
Jan 15, 2014·Expert Review of Anti-infective Therapy·Ardeshir RinehMichael R Hamblin
Apr 26, 2018·Frontiers in Microbiology·Holger Schäffler, Anne Breitrück
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H StubbeB Corthésy
Feb 1, 1997·Antimicrobial Agents and Chemotherapy·C P KellyC Pothoulakis
Mar 15, 2005·Gastroenterology·Stavros SougioultzisCiarán P Kelly
Oct 6, 2001·Gastroenterology Clinics of North America·L KyneC P Kelly
Jun 23, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sanskriti VarmaDaniel E Freedberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.