Immune response to different sequences of the EBNA I molecule in Epstein-Barr virus-related disorders and in autoimmune diseases

Journal of Autoimmunity
B MarchiniP Migliorini

Abstract

Epstein-Barr virus (EBV) infection is associated with production of autoantibodies. The N-terminal 35-58 sequence of EBNA I, one of the nuclear antigens encoded by EBV, is highly homologous to the C-terminal 95-119 region of the ribonucleoprotein SmD. Autoantibodies specific for SmD are present only in systemic lupus (SLE) sera and are therefore considered a serological marker of SLE. We measured antibodies to the EBNA I 35-58 sequence in EBV-related diseases and in autoimmune disorders. Antibodies to the EBNA I 35-58 peptide were present in 30% of normal sera, 12% Burkitt lymphoma, 22% infectious mononucleosis, 25% rheumatoid arthritis, 38% SLE and 33% Sjogren's syndrome. Antibodies to the SmD 95-119 peptide were detectable in 32% of SLE sera, 17% infectious mononucleosis and 12% Burkitt lymphoma. The specificity of anti-EBNA I 35-58 antibodies affinity-purified from nine sera was analysed by means of an inhibition assay. Only anti-EBNA I 35-58 antibodies affinity-purified from SLE sera have a similar affinity for the viral peptide and the SmD C-terminal one; they also bind the recombinant SmD in western blot. The results indicate that antibodies to EBNA I 35-58 are produced in normals, in EBV-related diseases and in autoimmun...Continue Reading

Citations

Mar 13, 2010·PloS One·Latisha D HeinlenJohn B Harley
Jan 20, 2011·PloS One·Pragya YadavLinda Spatz
Aug 22, 2006·Scandinavian Journal of Immunology·B T Kurien, R H Scofield
Jul 13, 2001·Infectious Disease Clinics of North America·E BouzaP Muñoz
Mar 29, 2002·Arthritis and Rheumatism·Theophany EystathioyEdward K L Chan
Jan 1, 2000·Arthritis and Rheumatism·S BlässG R Burmester
Jan 1, 1995·Viral Immunology·A D Cohen, Y Shoenfeld
Jul 15, 2005·Annals of the New York Academy of Sciences·Giuseppina MerliniPaola Migliorini
Jan 19, 2006·Journal of Clinical Immunology·Dirk LangnickelGabriela Riemekasten
Feb 4, 2006·Autoimmunity·Brian D PooleJudith A James
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P StrattaV Ghisetti
Sep 14, 2016·Immunity, Inflammation and Disease·Pragya YadavLinda A Spatz
May 20, 2005·Rheumatology·G Riemekasten, B H Hahn
Jan 1, 1995·Springer Seminars in Immunopathology·J H Vaughan
May 22, 2002·Annals of the New York Academy of Sciences·Elmar JaeckelMatthias Von Herrath
Jun 20, 2002·Journal of Biotechnology·Kristen Sadler, James P Tam
Sep 13, 1996·Journal of Immunological Methods·J P Tam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.