PMID: 9525580Apr 3, 1998Paper

Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor

Journal of Virology
I MaillardH Diggelmann

Abstract

Mouse mammary tumor virus (MMTV) is a retrovirus which induces a strong immune response and a dramatic increase in the number of infected cells through the expression of a superantigen (SAg). Many cytokines are likely to be involved in the interaction between MMTV and the immune system. In particular, alpha/beta interferon (IFN-alpha/beta) and gamma interferon (IFN-gamma) exert many antiviral and immunomodulatory activities and play a critical role in other viral infections. In this study, we have investigated the importance of interferons during MMTV infection by using mice with a disrupted IFN-alpha/beta or IFN-gamma receptor gene. We found that the SAg response to MMTV was not modified in IFN-alpha/betaR(0/0) and IFN-gammaR(0/0) mice. This was true both for the early expansion of B and T cells induced by the SAg and for the deletion of SAg-reactive cells at later stages of the infection. In addition, no increase in the amount of proviral DNA was detected in tissues of IFN-alpha/betaR(0/0) and IFN-gammaR(0/0) mice, suggesting that interferons are not essential antiviral defense mechanisms during MMTV infection. In contrast, IFN-gammaR(0/0) mice had increased amounts of IL-4 mRNA and an altered usage of immunoglobulin isotypes...Continue Reading

References

Jun 1, 1992·The Journal of Experimental Medicine·W HeldH Acha-Orbea
Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Feb 1, 1991·Current Opinion in Immunology·B Perussia
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PayneH Hengartner
May 1, 1987·Journal of Virology·C KozakA Vaidya
Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B Y Rubin, S L Gupta
Jan 1, 1980·Journal of Interferon Research·S K AryaR M Friedman
Feb 25, 1983·Journal of Immunological Methods·J D Sedgwick, P G Holt
Aug 1, 1995·Journal of Virology·M F van den BroekR M Zinkernagel
Jan 1, 1995·Annual Review of Immunology·H Acha-Orbea, H R MacDonald
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Oct 1, 1994·The Journal of Experimental Medicine·O KarapetianH Acha-Orbea
Sep 27, 1993·Journal of Immunological Methods·S L ReinerR M Locksley
Jul 1, 1996·Journal of Virology·J K HengM W Beilharz
Dec 1, 1995·Immunological Reviews·M F van den BroekM Aguet

❮ Previous
Next ❯

Citations

Feb 25, 2000·Allergy·G Tau, P Rothman
Sep 27, 2016·The Journal of General Virology·Victoria K Baxter, Diane E Griffin
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N GaoD Yuan
Mar 16, 2006·Journal of Virology·Carolina B LópezThomas M Moran
Apr 5, 2003·Immunobiology·Koko F HowellJames E Riggs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.