PMID: 7008448Jan 1, 1980Paper

Immune response to Mycobacterium lepraemurium: assessment of the humoral immune response in mice

Zentralblatt Für Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten Und Parasitologie
R G Navalkar, M V Kanchana

Abstract

Intraperitoneal infection of mice with Mycobacterium lepraemurium produced a primary immune response as represented by direct (IgM) plaque-forming cells at the splenic level within a short period after infection. This response was enhanced when animals were administered a second infection fifteen days after the first one. An identical situation was observed with the developed (IgG) plaques, although the magnitude of these plaques in animals given the second challenge was of a higher order than those given only one infection. In both instances, the number of plaques declined within a very short time after reaching a peak. Higher levels of both direct and developed plaques in animals given second infection was a consequence of the dual effect of antigenic stimulus offerred through the extracellular organisms in the second challenge and intracellular organisms from the previous challenge. The rapid decline, indicated a dampening of the immune response through restricted antigenic stimulus, not only due to all organisms becoming intracellular during the course of infection but also due to structural alterations in the spleens, caused by extensive proliferation of the infecting pathogen. Comparative analysis of the humoral immune re...Continue Reading

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