Immune response to postprimary tuberculosis in mice: Mycobacterium tuberculosis and Miycobacterium bovis bacille Calmette-Guérin induce equal protection

The Journal of Infectious Diseases
Hans-Joachim MollenkopfS H Kaufmann

Abstract

We addressed the question of whether protective immunity induced by natural infection with Mycobacterium tuberculosis and that induced by vaccination with Mycobacterium bovis bacille Calmette-Guerin (BCG) differ in the murine model. We infected mice with M. tuberculosis Erdman, cured them by chemotherapy, and subsequently reinfected them with a low dose of M. tuberculosis H37Rv. The course of tuberculosis was compared with that in mice previously vaccinated with BCG Danish 1331. Protection against postprimary M. tuberculosis infection did not differ significantly between the 2 groups. After challenge infection, numbers of interferon- gamma -positive splenocytes did not differ between mice with primary infection and vaccinated mice. Splenocytes from primary M. tuberculosis-infected mice conferred marginally higher protection than did those from BCG-vaccinated mice. Serum transfer did not protect against reinfection in either group. Our data emphasize that natural infection with M. tuberculosis and vaccination with BCG do not differ in their capacity to induce protective immunity against tuberculosis and support the notions that reinfection contributes to the development of active disease and that any novel vaccine against tuberc...Continue Reading

Citations

Mar 8, 2012·The Journal of Infectious Diseases·Angela M MinassianHelen McShane
Oct 15, 2005·Clinical Microbiology Reviews·T Mark Doherty, Peter Andersen
Aug 24, 2007·Genetic Vaccines and Therapy·Eduardo D C GonçalvesCélio L Silva
Nov 24, 2011·PloS One·Elma Z TchilianPeter C L Beverley
Apr 18, 2014·PloS One·Pere-Joan Cardona, Cristina Vilaplana
Feb 24, 2015·Frontiers in Microbiology·Yamilé López HernándezIsidre Gibert
Jun 21, 2011·Enfermedades infecciosas y microbiología clínica·Virgilio Bocanegra-GarcíaJosé Prisco Palma-Nicolás
Oct 14, 2016·Frontiers in Microbiology·Pere-Joan Cardona
Feb 7, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pere-Joan Cardona, Ann Williams
Oct 26, 2005·Trends in Immunology·Stefan H E Kaufmann
Jan 25, 2018·Immunology and Cell Biology·Pia SteiglerJoanna R Kirman
Jun 23, 2009·Expert Review of Vaccines·James A Triccas, Jonathan K Nambiar
Jul 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared L DelahayeKevin B Urdahl
Dec 10, 2016·International Journal of Mycobacteriology·Pere-Joan Cardona

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