PMID: 6166724Jul 1, 1981Paper

Immune response to stage-specific surface antigens of the parasitic nematode Trichinella spiralis

The Journal of Experimental Medicine
M PhilippB M Ogilvie

Abstract

Rats were infected with the nematode Trichinella spiralis and the primary serum antibody response to antigenic surface proteins of infective larvae, intestinal worms, and newborn larvae was studies. 1 wk after infection, the sera contained antibodies to surface antigens of both infective larvae and intestinal worms. These early sera, however, failed to react with newborn larvae surface antigens. In addition, adsorption of sera with living intestinal worms or infective larvae removed antibodies to surface antigens of the homologous stage only. Finally, the time-course of appearance of antibodies that mediate eosinophil adherence to the surface of each stage of the parasite. We concluded that in a primary infection in rats, the surface proteins of T. spiralis used in this study are antigenically stage specific. Furthermore, they could be targets for the stage-specific, antibody-dependent eosinophil-mediated destruction of this parasite, known to occur in vitro.

Citations

Jan 1, 1996·Parasitology Research·S M VenturielloG H Giambartolomei
Apr 1, 1988·Experimental Parasitology·D AbrahamM Mika-Grieve
Feb 1, 1987·International Journal for Parasitology·S R Smithers
Nov 1, 1988·International Journal for Parasitology·J H AdamsC Dobson
Dec 1, 1990·International Journal for Parasitology·K A KeithA Tait
Feb 1, 1991·International Journal for Parasitology·T GarateR M Parkhouse
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PhilippD A Denham
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Dissanayake, A K Chandana
Nov 1, 1982·Molecular and Biochemical Parasitology·D M Pratt, J R David
Feb 1, 1983·Molecular and Biochemical Parasitology·M JungeryR M Parkhouse
Feb 1, 1984·Molecular and Biochemical Parasitology·K P ForsythG F Mitchell
Mar 1, 1984·Molecular and Biochemical Parasitology·M Philipp, F D Rumjaneck
Mar 1, 1986·Molecular and Biochemical Parasitology·D W TaylorJ E McMahon
Sep 1, 1990·Molecular and Biochemical Parasitology·M L Rhoads, R H Fetterer
Jan 1, 1992·Parasitology Today·S M Politz, M Philipp
Jan 1, 1989·International Journal of Immunopharmacology·B E JohnsonD L Wassom
Jul 1, 1987·Veterinary Parasitology·P M Schantz
Jul 1, 1987·Veterinary Parasitology·W I Morrison
Nov 15, 2001·Veterinary Parasitology·J A Appleton, F Romaris
Dec 1, 1995·Journal of Helminthology·R IglesiasM L Sanmartín
Oct 1, 1988·Parasitology·M LastreA Capron
Jan 1, 1986·Parasitology·M E SelkirkR M Maizels
Nov 26, 2010·Parasitology·Aleksandar ZocevicPascal Boireau
Nov 1, 1992·Research in Veterinary Science·D C De GraafJ Vercruysse
Jun 1, 1992·Experimental Parasitology·R G Bell
Feb 1, 1987·Experimental Parasitology·H P MartiH R Gamble
Feb 1, 1992·Experimental Parasitology·N Storey, M Philipp
Jun 1, 1985·Experimental Parasitology·K D Murrell
Sep 23, 2006·Experimental Parasitology·Maria Del Rosario Salinas-TobonJavier Hernandez-Sanchez
Jan 1, 1981·Parasite Immunology·R M ParkhouseB M Ogilvie
Aug 22, 2006·Trends in Parasitology·Jean Dupouy-Camet, Isabelle Vallée

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