Immune response to Taenia solium cysticerci after anti-parasitic therapy

International Journal for Parasitology
Aloukick K SinghKashi Nath Prasad

Abstract

Albendazole is the drug of choice for Taenia solium infection. Concomitant administration of steroid has been advocated to avoid adverse reactions to albendazole therapy in neurocysticercosis. Some T. solium cysticerci (larvae) respond to albendazole therapy while others do not and the reasons remain unexplained. We hypothesise that the immune response differs between treatment responder and non-responder cysticerci and this may determine the outcome. Twenty swine naturally infected with T. solium were purchased from the market and the infection was confirmed by magnetic resonance imaging. Swine were divided into two groups; swine in group 1 were treated with albendazole and those in group 2 were treated with albendazole plus steroid (prednisolone). All the animals underwent follow-up MRIs at 6 and 12 weeks after start of therapy and were then sacrificed. Tissues surrounding the cysticerci were collected and studied for the expression of different cytokines by reverse transcriptase PCR and ELISA. Albendazole therapy was found to be more effective in parasite killing than albendazole plus steroid (94.11% versus 70.96%, P=0.011). Albendazole therapy provoked a pro-inflammatory, Th1 (IFN-γ) and pleiotropic (IL-6) cytokine response...Continue Reading

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Dec 17, 2015·Parasite Immunology·A FleuryE Sciutto
Jul 10, 2016·Asian Pacific Journal of Tropical Medicine·Mei FanYan-Bing Fan
Nov 27, 2018·Journal of Clinical Pharmacology·Rocio OsorioAgnès Fleury
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May 29, 2020·Clinical Microbiology Reviews·Hector H GarciaRobert H Gilman
Dec 24, 2019·Frontiers in Cellular and Infection Microbiology·Naina AroraAmit Prasad
Apr 2, 2021·Expert Review of Anti-infective Therapy·Pedro T Hamamoto FilhoAgnès Fleury

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