PMID: 6974764Jul 1, 1981Paper

Immune responses in experimental allergic neuritis

Journal of Neurology, Neurosurgery, and Psychiatry
R A HughesS Leibowitz

Abstract

The antibody and cell mediated immune responses were investigated in inbred Lewis rats with experimental allergic neuritis (EAN) induced by either P2, a protein purified from the bovine cauda equina nerve roots, or whole bovine nerve root myelin. In the P2 immunised animals both antibodies to P2 detected by radioimmunoassay and cell-mediated immunity to P2 assayed by skin testing appeared before the onset of EAN and persisted during and after the disease. In the myelin immunised animals the antibody titres were lower and somewhat delayed and the skin tests became negative at the height of the disease. Complement-fixing antibodies to galactocerebroside, which have been implicated in the production of demyelination under some circumstances, could not be detected in the serum after immunisation with either P2 or myelin. EAN was transferred passively with lymph node cells from rats immunised with either P2 or myelin although anti-P2 antibodies could not be detected in the serum of recipients with EAN. The results favour a cell-mediated immune response to P2 as the most important pathogenetic mechanism in EAN induced wtih whole myelin in the rat.

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Citations

Jul 1, 1990·Muscle & Nerve·J L RosenA Rostami
Jan 1, 1985·Acta Neuropathologica·M K MoreyH C Powell
Jan 1, 1983·Acta Neuropathologica·J J GilbertA F Hahn
Jan 1, 1985·Acta Neuropathologica·A F HahnJ J Gilbert
Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Dec 1, 1986·Agents and Actions·C LiningtonR Meyermann
Dec 1, 1983·Journal of the Neurological Sciences·K SaidaH Nishitani
Jun 1, 1986·Journal of the Neurological Sciences·Y GobanM Kameyama
Jul 1, 1987·Journal of the Neurological Sciences·P MilnerR A Hughes
Jan 1, 1988·Journal of the Neurological Sciences·H WiethölterK Wessel
Mar 1, 1995·Journal of Neuroimmunology·J M SpiesJ G McLeod
Sep 17, 1988·Lancet
May 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·J B WinerV Yewdall
Apr 8, 1998·Annual Review of Neuroscience·T W HoJ W Griffin
Mar 13, 2014·ILAR Journal·Betty Soliven
Oct 5, 2001·Journal of Neuroimmunology·I DahlmanR Weissert
Sep 1, 1984·Journal of Neuroimmunology·J V BrosnanP K Thomas
Aug 1, 1984·Journal of Neuroimmunology·R A HughesH Thompson
Sep 1, 1987·Brain Research·T E FeasbyM Neilson
Dec 22, 1999·Experimental and Molecular Pathology·O Lilje, P J Armati
Jan 1, 1988·Annals of the New York Academy of Sciences·H P HartungK V Toyka
Jul 1, 1985·Acta Neurologica Scandinavica·G SoldersS Hansson
Sep 1, 1988·European Archives of Psychiatry and Neurological Sciences·J KornhuberW E Wanner

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