PMID: 9529052Apr 7, 1998Paper

Immune responses of specific-pathogen-free mice to chronic Helicobacter pylori (strain SS1) infection

Infection and Immunity
R L FerreroA Labigne

Abstract

A model permitting the establishment of persistent Helicobacter pylori infection in mice was recently described. To evaluate murine immune responses to H. pylori infection, specific-pathogen-free Swiss mice (n = 50) were intragastrically inoculated with 1.2 x 10(7) CFU of a mouse-adapted H. pylori isolate (strain SS1). Control animals (n = 10) received sterile broth medium alone. Animals were sacrificed at various times, from 3 days to 16 weeks postinoculation (p.i.). Quantitative culture of gastric tissue samples from inoculated mice demonstrated bacterial loads of 4.0 x 10(4) to 8 x 10(6) CFU per g of tissue in the animals. Infected mice had H. pylori-specific immunoglobulin M (IgM) and IgG antibodies in serum (at day 3 p.i.) and IgG and IgA antibodies in their gastric contents (weeks 4 and 16 p.i.) and saliva (week 16 p.i.). Mucosal IgM antibodies were not detected. Histological examination of the gastric mucosae from control and infected mice revealed mild chronic gastritis, characterized by the presence of polymorphoneutrophil cell infiltrates and submucosal lymphoid aggregates, in infected animals at 16 weeks p.i. Differences in the quantities of IgG1 and IgG2a subclass antibodies detected in the sera of mouse strains (Sw...Continue Reading

References

May 1, 1991·Journal of Gastroenterology and Hepatology·J J Misiewicz
Apr 15, 1985·The Medical Journal of Australia·B J MarshallR J Glancy
Feb 24, 1984·Journal of Immunological Methods·C O ElsonJ Lefkowitz
Sep 1, 1996·The Journal of Infectious Diseases·J C AthertonM J Blaser
Feb 1, 1997·Research in Immunology·R L Ferrero

❮ Previous
Next ❯

Citations

Apr 7, 2010·Infection and Immunity·Damien LeducHilde de Reuse
Dec 15, 2010·MBio·Alexandra GrubmanRichard L Ferrero
Dec 29, 2013·Applied Microbiology and Biotechnology·Le GuoYingying Xing
Oct 15, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Madleen BussePhilip C Andrews
Jul 15, 1999·The Journal of Antimicrobial Chemotherapy·P J JenksA Labigne
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eyleen J O'RourkeJ Pablo Radicella
Dec 12, 2007·Infection and Immunity·Richard L FerreroSylvie Mémet
Aug 6, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Philip C AndrewsJonathan G MacLellan
Jul 21, 2005·Journal of Bacteriology·Koji HiratsukaEleonora Altman
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cody C AllisonRichard L Ferrero
Dec 5, 2006·Applied and Environmental Microbiology·Mai Ping TanRichard A Strugnell
Oct 7, 2006·Current Opinion in Gastroenterology·K T Wilson, G T Fantry
Feb 12, 2015·Helicobacter·Lorinda TurnerRichard L Ferrero
Sep 23, 2003·Infection and Immunity·Stéphanie Bury-MonéHilde De Reuse
Aug 21, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Philip C AndrewsAmelia Vom
Mar 5, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Philip C AndrewsJames W Taylor
Jul 24, 2010·Human Mutation·Michael P GantierBryan R G Williams
Nov 6, 2009·Cellular Microbiology·Maria KaparakisRichard L Ferrero
Sep 10, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Amita PathakPhilip C Andrews

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.