Immune responses to Epstein-Barr virus lytic proteins in patients with nasopharyngeal carcinoma

Journal of Medical Virology
Mei-Ying LiuChing-Hwa Tsai

Abstract

Immune responses to three Epstein-Barr virus (EBV) lytic proteins, DNase, thymidine kinase (TK), and BMRF-1 gene products (50/52 kDa diffused early antigen, EA-D complex) were determined in EBV-infected control individuals and patients with nasopharyngeal carcinoma (NPC). Immunofluorescence assays (IFA) were used to detect their humoral immune responses using recombinant EBV lytic proteins expressed in a baculovirus system as antigens. Cell proliferation assays were performed to evaluate their cellular immune responses by monitoring 3H-thymidine incorporation. Seventy patients with NPC and 32 non-cancer controls were analyzed. The results of IFA showed antibody titers to all three EBV lytic proteins to be higher in the patients with NPC especially for the IgA class. Positivity rates of the three IgA antibodies also were higher in the patients with NPC population. Furthermore, the profiles of the IgA antibodies correlated with those to total early antigens (EA) expressed in the early phase and viral capsid antigen (VCA) expressed in the late phase, of EBV replication. The most interesting finding was that antibody titers to the three EBV lytic proteins were associated significantly with metastases of cervical lymph nodes in pati...Continue Reading

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Citations

May 6, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Dewi K ParamitaJaap M Middeldorp
Sep 13, 2005·Structure·Nicolas TarbouriechWim P Burmeister
Sep 15, 2007·Journal of Medical Virology·Dewi K ParamitaJaap M Middeldorp

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