Immune responses to individual rotavirus proteins following heterologous and homologous rotavirus infection in mice

The Journal of Infectious Diseases
S I IshidaH B Greenberg

Abstract

Serum and intestinal humoral immune responses to rotavirus proteins VP2, VP4, VP6, VP7, NSP2, and NSP4 were quantitatively compared in mice infected with a homologous murine rotavirus (EHPw) or a heterologous simian rotavirus (RRV). Viral protein-specific antibody responses were measured by an immunohistochemistry assay that uses recombinant baculovirus-expressed rotavirus proteins as antigens. In serum, IgG responses to VP6 were dominant and comparable in both RRV- and EHPw-infected groups, but responses to VP2, VP4, VP7, and NSP2 were higher in RRV infection. In feces, IgA responses to VP2, VP4, and VP6 were higher in EHPw-infected mice, but responses to VP7 and NSP2 were detected only in the RRV-infected group. These findings indicate that immune responses to homologous and heterologous rotavirus infection vary both quantitatively and qualitatively. Differences in humoral responses may play a role in the differences in protection induced following homologous or heterologous rotavirus infection.

Citations

Sep 29, 1999·Journal of Medical Virology·K JohansenL Svensson
Apr 2, 2005·Viral Immunology·Judith M BallRebecca D Parr
May 30, 2015·Vaccine·Somayeh JalilvandZabihollah Shoja
Mar 10, 2011·Virology Journal·Karen KnippingBelinda Van't Land
Nov 28, 2012·Journal of Virological Methods·Owen KavanaghMary K Estes
Jun 1, 2001·Nature Biotechnology·J Yu, W H Langridge
Apr 1, 1999·The Journal of Infectious Diseases·M A Franco, H B Greenberg
Dec 1, 2013·Microbiology Spectrum·Manuel A Franco, Harry B Greenberg

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