Feb 5, 2002

Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients

Journal of Clinical Microbiology
T Mark DohertyPeter Andersen


Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

Mentioned in this Paper

ESAT gene
Immune Response
Bacterial Proteins
Antigens, Bacterial
Specific antigen
Mycobacterium tuberculosis H37Rv
Notification, Partner
Nongranular Leukocyte

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