Immune signaling pathways activated in response to different pathogenic micro-organisms in Bombyx mori

Molecular Immunology
Wei LiuChengliang Gong

Abstract

The JAK/STAT, Toll, Imd, and RNAi pathways are the major signaling pathways associated with insect innate immunity. To explore the different immune signaling pathways triggered in response to pathogenic micro-organism infections in the silkworm, Bombyx mori, the expression levels of the signal transducer and activator of transcription (BmSTAT), spatzle-1 (Bmspz-1), peptidoglycan-recognition protein LB (BmPGRP-LB), peptidoglycan-recognition protein LE (BmPGRP-LE), argonaute 2 (Bmago2), and dicer-2 (Bmdcr2) genes after challenge with Escherichia coli (E. coli), Serratiamarcescens (Sm), Bacillus bombyseptieus (Bab), Beauveriabassiana (Beb), nucleopolyhedrovirus (BmNPV), cypovirus (BmCPV), bidensovirus (BmBDV), or Nosemabombycis (Nb) were determined using real-time PCR. We found that the JAK/STAT pathway could be activated by challenge with BmNPV and BmBDV, the Toll pathway could be most robustly induced by challenge with Beb, the Imd pathway was mainly activated in response to infection by E. coli and Sm, and the RNAi pathway was not activated by viral infection, but could be triggered by some bacterial infections. These findings yield insights into the immune signaling pathways activated in response to different pathogenic micro-...Continue Reading

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Citations

Dec 2, 2017·Archives of Insect Biochemistry and Physiology·Chen ChenLei Wang
Nov 6, 2018·Archives of Insect Biochemistry and Physiology·Jiawei ZhangChaoliang Liu
Jul 6, 2020·Archives of Insect Biochemistry and Physiology·Taohong LiLei Wang
Sep 18, 2020·International Journal of Molecular Sciences·Hye Jin KoYeon Soo Han
Apr 9, 2019·International Journal of Genomics·Tieshan FengTingcai Cheng
Jan 9, 2021·Archives of Insect Biochemistry and Physiology·Xue-Yang WangYang-Chun Wu
Sep 19, 2020·Journal of Invertebrate Pathology·Tao GengShuchang Wang
Feb 18, 2018·Journal of Invertebrate Pathology·Peng LüKeping Chen
Mar 2, 2021·Frontiers in Immunology·Liang Jiang
Feb 6, 2021·Pathogens and Disease·Daniel F Q Smith, Arturo Casadevall
Feb 21, 2019·Molecular Immunology·Vincent ViscontiIsabelle Darboux

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