Immune-specific production of gamma interferon in human lymphocyte cultures in response to mumps virus.

Infection and Immunity
T Nakayama

Abstract

The production of interferon (IFN) was investigated in human peripheral lymphocyte cultures stimulated by mumps virus. IFN-alpha and IFN-gamma were produced in lymphocyte cultures from immune donors. However, no IFN-gamma was produced in lymphocyte cultures from nonimmune donors. IFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes. An increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures. The production of IFN-gamma by T lymphocytes was found to depend on prior, possibly cellular, immunity.

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Citations

Nov 19, 2013·Internal Medicine·Takahito NeiAkihiro Shinoyama
Aug 21, 2015·PloS One·Alicja PacholewskaVincent Gerber
Jan 1, 1997·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·N SuzukiY Fujimura
May 1, 1985·Journal of Virology·J P AnderssonM DeLey
May 1, 1986·Journal of Clinical Microbiology·A D D'AndreaR A Polin

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