Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis

Scandinavian Journal of Gastroenterology
Changbin ShiRoland Andersson

Abstract

Acute pancreatitis (AP) is an inflammatory disorder that develops a complex cascade of immunological events. The local and systemic immune status and inflammatory response might contribute to the understanding of underlying pathophysiological mechanisms and potential treatment. Severe AP was induced by intraductal perfusion of 5% sodium taurodeoxycholate in rats. mRNA expression of cytokines and chemokines was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and NF-kappaB activation was assessed by electrophoretic mobility shift assay in fresh pancreatic acini and circulating monocytes 1, 3, 6 or 9 h after sham operation, induction of AP or N-acetylcysteine (NAC) pretreatment. Flow cytometry was performed on cells obtained from the peripheral blood. An inverse relationship in pancreatic and circulating monocytic NF-kappaB activation was detected 6 and 9 h after induction of AP. NAC further suppressed monocytic NF-kappaB activation induced by AP as seen 9 h after induction of AP. A marked constitutive increase in the expression of IL-6, CINC and MCP-1 was seen in pancreatic acini, whereas no change in mRNA expression of inflammatory mediators was observed in circulating monocytes 6 h after induction of AP. ...Continue Reading

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Citations

Jan 18, 2008·World Journal of Gastroenterology : WJG·Ping XueZong-Wen Huang
Oct 14, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·S RegnérA Borgström
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Sep 17, 2009·Digestive Diseases and Sciences·Kathryn M DalbecNicholas J Zyromski
Apr 3, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·YinFeng Shen, Nai-Qiang Cui
Sep 16, 2010·Inflammation·ZhiMin LiuJing Yang
Jul 5, 2011·Molecular Biology Reports·Lu ZhongkaiChen Weichang
Apr 21, 2010·Inflammation·YinFeng ShenErPeng Zhao

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