PMID: 8586776Jun 1, 1995Paper

Immune status of children with phenylketonuria

Journal of the American College of Nutrition
S S GropperS J Weese

Abstract

To determine the effect of differences in plasma phenylalanine (Phe) concentrations (< 363 umol/L, 363 to 605 umol/L, and > 605 umol/L) on hematological and immunological parameters in 22 children with phenylketonuria (PKU). Children with PKU were divided into one of three groups based on fasting plasma Phe levels. Hematologic and immunologic parameters of the children with PKU were compared between the groups and also compared with published values from age-matched children without PKU. Hematologic and immunologic parameters did not differ among children with different plasma Phe concentrations. Specifically, no significant differences between groups of PKU children with differing plasma Phe levels were found for plasma levels of albumin, hemoglobin, amino acids, IgM, complement C3, interleukins 1 and 2, erythrocyte, leukocyte and differential cell counts, hematocrit, percentages and numbers of CD4+, CD8+, CD3+ and total lymphocytes, or CD4 to CD8 ratio. Mean plasma IgG and IgA concentrations of the PKU children were, however, significantly lower than values from similar aged children. Moreover, positive correlations were obtained between plasma albumin and percentages and numbers of CD3+ and CD4+, between plasma IgG and inter...Continue Reading

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Citations

Oct 13, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marion DeonCarmen R Vargas
Oct 2, 2015·Aging and Disease·Patrícia Fernanda SchuckGustavo Costa Ferreira
Apr 20, 2016·Experimental Neurology·Gudrun SchlegelGabriele M Rune
Apr 1, 1997·Journal of the American College of Nutrition·R O FischK Michals
Nov 2, 2019·Journal of Inherited Metabolic Disease·Emma R L C VardyDenise L Hofman

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