PMID: 9416568Aug 1, 1997Paper

Immune stimulation may contribute to enhanced progression of SIV induced disease in rhesus macaques

Journal of Medical Primatology
T M FolksA A Ansari

Abstract

A number of rhesus macaques experimentally infected with SIV isolates such as SIVmac251, fail to seroconvert, develop high plasma viremia and die rapidly (within 6-7 months p.i.). We hypothesized that such rapid progression is a result of a state of hyperimmune activation and concomitant immune suppression of these animals at the time of virus challenge. In efforts to test the hypothesis that immune activation leads to rapid progression of lentivirus-induced disease, adult rhesus macaques were infected with SIV mac251 and received an alternate monthly schedule of repeated immunization with allogeneic cells, keyhole limpet hemocyanin and tetanus toxoid (group I). For purposes of controls, a group of monkeys was infected with the same pool and dose of virus but were not immunized (group II) and a group was immunized with the same schedule of multiple antigens as group I but were not infected with SIV (group III). All the animals in group I (n = 3) either failed to seroconvert or developed very low levels of SIV antibodies, had high plasma p27 defined antigenemia, and died within 8 months (2/3 died within 4 months). Of the animals in group II (n = 8), two patterns emerged as we had noted before. One subgroup (3 animals), displayed...Continue Reading

References

Oct 1, 1989·AIDS Research and Human Retroviruses·E NorrbyR A Lerner
May 1, 1989·Veterinary Immunology and Immunopathology·H M McClureA Brodie
Dec 1, 1987·The Journal of General Virology·M D DanielR C Desrosiers
Apr 1, 1995·Immunology Today·Z BentwichZ Weisman
Mar 1, 1995·The Journal of Infectious Diseases·L Corey
Mar 1, 1995·The Journal of Infectious Diseases·O A AnzalaF A Plummer
Feb 4, 1993·The New England Journal of Medicine·G PantaleoA S Fauci
Aug 22, 1996·Nature·C M Hill, D R Littman

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Citations

Nov 2, 1999·Micron : the International Research and Review Journal for Microscopy·J R Harris, J Markl
Mar 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jung Joo HongFrancois Villinger

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