Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes

Gastroenterology
Rifaat SafadiS L Friedman

Abstract

Immunomodulatory cytokines, including interleukin-10 (IL-10), may mediate hepatic fibrosis. We generated transgenic (TG) mice with hepatocyte expression of rat IL-10 (rIL-10) to assess its impact on lymphocyte subsets and activation of hepatic stellate cells following liver injury from carbon tetrachloride (CCl 4 ) or thioacetamide (TAA). Fibrosis was reduced in the TG animals in both models, which was not explained solely by differences in liver injury. By fluorescence-activated cell sorter (FACS), there were less CD4+ T cells in naive TG mice, and, following fibrosis induction, CD4+ T cells decreased only in wild-type (WT) mice, whereas increases in CD8+ T cells seen in WT animals were significantly attenuated in TG mice. Subtotal irradiation diminished fibrosis equally in both WT and TG groups, suggesting that rIL-10's antifibrotic effect was lymphocyte mediated. To assess the role of lymphocytes on stellate cell activation, either whole splenic lymphocytes, CD4+, or CD8+ T-cell subsets from WT animals with CCl 4 fibrosis were adoptively transferred to severe combined immunodeficiency (SCID) recipients, which led to stellate cell activation and fibrogenic stimulation as assessed by expression of transforming growth factor (T...Continue Reading

Citations

Aug 20, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Felice MarinosciGianluigi Giannelli
Oct 14, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amjad HoraniRifaat Safadi
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian WahlJörg Reimann
Jan 31, 2007·Clinical Science·Neil C Henderson, John P Iredale
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Zhen Fan YangSheung Tat Fan
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anne RullierJean Rosenbaum
Feb 19, 2008·Clinical and Experimental Immunology·A A HigaziR Safadi
Mar 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Zhen Fan YangSheung Tat Fan
Jun 10, 2009·Journal of Gastroenterology·Nobuyuki TanakaHideki Fujii
Jun 18, 2009·Seminars in Immunopathology·Fabio MarraAngela Provenzano
Oct 8, 2009·Genes & Nutrition·Emanuele Albano, Matteo Vidali
Aug 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yury Popov, Detlef Schuppan
Jan 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·David H AdamsHartmut Jaeschke
Dec 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zixue JinZhigang Tian
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Si-Jie WuYa-Hui Chuang
Nov 2, 2011·Therapeutic Advances in Gastroenterology·Michal Cohen-Naftaly, Scott L Friedman
Mar 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Po-Sung ChuToshifumi Hibi
Apr 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander WehrFrank Tacke
Sep 27, 2013·Angiogenesis·Sandra M BloisGuillermo Mazzolini
Aug 21, 2013·Immunological Reviews·Lucy Golden-Mason, Hugo R Rosen
May 27, 2014·BioMed Research International·Elena RigamontiSilvia Brunelli
Nov 25, 2014·Digestive Diseases and Sciences·Yoon Seok RohBumseok Kim
May 9, 2015·International Journal of Inflammation·Florent DuvalDelia Elva Cruz-Vega
Apr 16, 2020·Cells·Erica LafozVirginia Hernández-Gea
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Scott L Friedman
Nov 6, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·John A MengsholHugo R Rosen
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul D Berk
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michal AbelSophie Caillat-Zucman
Feb 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ogyi ParkBin Gao
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Scott L FriedmanD Montgomery Bissell
Dec 6, 2008·Parasitology Research·Maria Irma Seixas DuarteFelipe Francisco Tuon
Aug 14, 2010·Gastroenterology Research and Practice·Gakuhei SonIan N Hines
Jul 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keiichi IshiharaSatoshi Akiba
Aug 2, 2013·European Journal of Gastroenterology & Hepatology·Jonathan ArauzPablo Muriel
Mar 10, 2010·Basic & Clinical Pharmacology & Toxicology·Zvi AckermanMaria Grozovski
Jul 23, 2013·The Journal of Clinical Investigation·Anthony J BonitoKonstantina Alexandropoulos
Jul 16, 2014·Nature Reviews. Gastroenterology & Hepatology·Deepak JoshiKosh Agarwal
Jul 11, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mladen I YovchevMichael Oertel
Jul 15, 2015·Clinical and Molecular Hepatology·Yoon Ok JangSang Ok Kwon

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