Jun 26, 2018

Immune suppression and reversal of the suppressive tumor microenvironment

International Immunology
Kanako ShimizuShin-Ichiro Fujii

Abstract

Most tumors employ multiple strategies to attenuate T-cell-mediated immune responses. In particular, immune suppression surrounding the tumor is achieved by interfering with antigen-presenting cells and effector T cells. Controlling both the tumor and the tumor microenvironment (TME) is critical for cancer treatment. Checkpoint blockade therapy can overcome tumor-induced immune suppression, but more than half of the patients fail to respond to this treatment; therefore, more effective cancer immunotherapies are needed. Generation of an anti-tumor immune response is a multi-step process of immune activation against the tumor that requires effector T cells to recognize and exert toxic effects against tumor cells, for which two strategies are employed-inhibition of various types of immune suppressor cells, such as myeloid cells and regulatory T cells, and establishment of anti-tumor immune surveillance including, activation of natural killer cells and cytotoxic T cells. It was recently shown that anti-cancer drugs not only directly kill tumor cells, but also influence the immune response to cancer by promoting immunogenic cell death, enhancing antigen presentation or depleting immunosuppressive cells. Herein, we review the mechani...Continue Reading

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References

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Immune Response
Tumor Immunity
Antineoplastic Agents
T-Lymphocyte
Exertion
Immune Effector Cell
Decreased Immunologic Activity [PE]
Antigen-Presenting Cells
Cancer Microenvironment

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