Immune suppression leading to hepatitis C virus re-emergence after sustained virological response

Journal of Medical Virology
Amy LinGerond Lake-Bakaar

Abstract

Sustained virological response SVR is defined as undetectable HCV RNA in plasma 6 months after therapy has been discontinued. Relapse or re-emergence of viremia after SVR is rare. We report two patients that relapsed when immune suppressive therapy was given within a few weeks of achieving SVR. Patient 1 received prednisone for bronchitis and patient 2 relapsed soon after immune suppression was started post renal transplantation. These data suggest that the early phase of SVR might be associated with incomplete protective immunity. They suggest that sterilizing immunity with complete elimination of virus is unlikely. The cases also caution against the use of immune suppressive therapy in the immediate aftermath of SVR.

References

Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S E BassettR E Lanford
May 4, 2002·Lancet·Shruti H MehtaDavid L Thomas
Jan 15, 2004·Journal of Virology·Robert E LanfordDavid L Thomas
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fareed RahmanBarbara Rehermann
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johannes WiegandHeiner Wedemeyer
Oct 19, 2004·Annual Review of Microbiology·Naglaa H ShoukryChristopher M Walker
Dec 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marek RadkowskiTomasz Laskus
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KaplanKyong-Mi Chang
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raymond T Chung
May 13, 2006·Science·Adolfo García-Sastre, Christine A Biron

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Citations

May 19, 2010·Inflammatory Bowel Diseases·Jason K HouUma Mahadevan
Jun 28, 2012·World Journal of Gastroenterology : WJG·Vicente CarreñoJuan Antonio Quiroga
Jul 9, 2014·The Journal of Clinical Investigation·Naga Suresh VeerapuBarbara Rehermann
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alina M AllenEdward V Loftus
Jul 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leonard B Seeff
Jun 26, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kei FujiwaraHarvey J Alter
Dec 17, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Florence NicotJacques Izopet
Jun 5, 2014·Journal of Medical Virology·Pavlina Dzekova VidimliskiAleksandar Sikole
Jan 15, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Tram N Q PhamTomasz I Michalak
Oct 21, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Latifa T F Yeung, Eve A Roberts
Nov 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Parag MahaleHarrys A Torres
Dec 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khurram BariShimul A Shah
Jan 1, 2013·Virology : Research and Treatment·Mohit SehgalPooja Jain
May 19, 2009·Journal of Clinical Gastroenterology·Andrew Aronsohn, Nancy Reau
Oct 31, 2009·World Journal of Hepatology·Patricia Baré
Dec 3, 2014·Internal Medicine·Nami MoriKazuaki Chayama
Apr 3, 2015·World Journal of Gastroenterology : WJG·Juan-Ramón LarrubiaEduardo Sanz-de-Villalobos
Jul 2, 2009·The International Journal of Artificial Organs·Fabrizio FabriziPaul Martin
Jul 28, 2019·Archives of Virology·Tahereh DonyaviMaryam Esghaei

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