Immune suppression to nucleosides: differences between NZB and NZW mice

European Journal of Immunology
M C YoungY Borel

Abstract

Previous studies (Y. Borel and M.C. Young, Proc. Natl. Acad. Sci. USA 1980 77: 1593) have shown that one can raise nucleic acid-specific suppressor T cells which diminish either the T-dependent immune response in vivo or the T-independent immune response in vitro. The results presented here confirm and extend these observations in several different strains of mice. Administration of nucleoside-modified spleen cells diminishes antibody-forming cells to nucleoside in mice immunized with nucleoside linked to keyhole limpet hemocyanin (KLH), Immune suppression was obtained in all strains except SJL and NZW, which are known to be high responders to denatured DNA. Both the primary and secondary immune responses were suppressed in C57BL/6 mice. Autologous cells exhibit a different ability to function as carriers. Spleen cells are the most effective, and to a certain extent, thymus cells. In contrast, bone marrow cells and red cells fail to induce immune suppression. A strain difference was found between NZB and NZW mice in their susceptibility to immunosuppression by nucleoside-modified spleen cells. Whereas NZB mice are high responders to nucleoside-KLH, they were easily suppressed by nucleoside coupled to spleen cells. In contrast, ...Continue Reading

References

Jun 1, 1978·The Journal of Experimental Medicine·J G Knight, D D Adams
Jan 1, 1974·Current Topics in Microbiology and Immunology·N Talal, A D Steinberg
Aug 1, 1974·European Journal of Immunology·G M Shearer
Jul 1, 1973·European Journal of Immunology·J A Hamilton, J F Miller
Mar 1, 1980·The Journal of Experimental Medicine·Y BorelC L Reinisch
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y Borel, M C Young
Jan 1, 1980·Immunological Reviews·H N ClamanJ W Moorhead
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R F SilicianoH S Shin
Mar 15, 1980·Cellular Immunology·C E MoodyM E Weksler
Jan 1, 1980·Immunological Reviews·M I Greene, B Benacerraf
Jan 1, 1980·Immunological Reviews·T RamosG Möller
Jan 1, 1980·Immunological Reviews·D W ScottJ T Li

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Citations

Jan 1, 1984·Springer Seminars in Immunopathology·Y Borel
Jul 15, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yuxin LiuAndras Perl
Dec 1, 1984·Scandinavian Journal of Immunology·Y ImaiT Osawa

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