Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells

Stem Cells International
Minhwa ParkKyung-Ha Ryu

Abstract

Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.

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Citations

Feb 28, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eun Mi SongKi Nam Shim
Aug 11, 2017·Muscle & Nerve·Saeyoung ParkSung-Chul Jung
Sep 13, 2019·Cell Transplantation·Yu YouZuo-Jin Liu
Jan 18, 2020·PloS One·Rafael Vessecchi Amorim ZafalonMarcio Antonio Brunetto
Feb 12, 2020·Journal of Cellular Physiology·Mehri ShahirEsmaeil Mortaz
Mar 29, 2018·PloS One·Jared A JaffeyAmy E DeClue
Aug 30, 2017·Molecular Medicine Reports·Yu-Hee KimKyung-Ha Ryu
Jul 18, 2018·Stem Cells International·Mengyuan WangLiang Xie

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Methods Mentioned

BETA
density gradient centrifugation
flow cytometry

Software Mentioned

GraphPad
Cell Quest
GraphPad Prism

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