Immune system and melanoma biology: a balance between immunosurveillance and immune escape

Oncotarget
Anna PassarelliFrancesco Silvestris

Abstract

Melanoma is one of the most immunogenic tumors and its relationship with host immune system is currently under investigation. Many immunomodulatory mechanisms, favoring melanomagenesis and progression, have been described to interfere with the disablement of melanoma recognition and attack by immune cells resulting in immune resistance and immunosuppression. This knowledge produced therapeutic advantages, such as immunotherapy, aiming to overcome the immune evasion. Here, we review the current advances in cancer immunoediting and focus on melanoma immunology, which involves a dynamic interplay between melanoma and immune system, as well as on effects of "targeted therapies" on tumor microenvironment for combination strategies.

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Methods Mentioned

BETA
MDA

Clinical Trials Mentioned

NCT02178722
NCT02327078
NCT01656642
NCT02130466
NCT02263508

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