Immune system and new avenues in Parkinson's disease research and treatment.

Reviews in the Neurosciences
Ava NasrolahiJavad Mahmoudi

Abstract

Parkinson's disease (PD) is a progressive neurological disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. However, although 200 years have now passed since the primary clinical description of PD by James Parkinson, the etiology and mechanisms of neuronal loss in this disease are still not fully understood. In addition to genetic and environmental factors, activation of immunologic responses seems to have a crucial role in PD pathology. Intraneuronal accumulation of α-synuclein (α-Syn), as the main pathological hallmark of PD, potentially mediates initiation of the autoimmune and inflammatory events through, possibly, auto-reactive T cells. While current therapeutic regimens are mainly used to symptomatically suppress PD signs, application of the disease-modifying therapies including immunomodulatory strategies may slow down the progressive neurodegeneration process of PD. The aim of this review is to summarize knowledge regarding previous studies on the relationships between autoimmune reactions and PD pathology as well as to discuss current opportunities for immunomodulatory therapy.

References

Nov 1, 1988·The International Journal of Neuroscience·R A Barker, A P Cahn
Dec 1, 1995·Journal of Neuroimmunology·A SvenningssonS Stemme
Dec 1, 1995·Current Opinion in Immunology·A CoutinhoS Avrameas
Jun 18, 2002·Acta Neurologica Scandinavica·M ZappiaA Quattrone
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krishnan SriramJames P O'Callaghan
Nov 14, 2002·Experimental Neurology·Estelle RousseletEtienne C Hirsch
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter TeismannSerge Przedborski
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pia KivisäkkRichard M Ransohoff
Aug 20, 2003·Archives of Neurology·Honglei ChenAlberto Ascherio
Aug 21, 2003·Journal of Neuroscience Research·Viviana OjedaMaría Estela Andrés
Sep 4, 2003·Annals of Neurology·Patrick M Abou-SleimanNicholas W Wood
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Dec 10, 2003·Brain : a Journal of Neurology·Rina BandopadhyayAndrew J Lees
Jan 23, 2004·Nature·Marcelo T MiraErwin Schurr
May 12, 2004·Current Pharmaceutical Design·Dilek Dogrukol-AkNese Tuncel
Jan 26, 2005·Annals of Neurology·Yasuomi OuchiTatsuo Torizuka
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhangJing Zhang
Apr 1, 2005·The Journal of Biological Chemistry·Linan ChenXiaoxi Zhuang
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eryn GangiBellur S Prabhakar
Sep 27, 2005·Neurobiology of Disease·Alexander GerhardDavid J Brooks
Oct 6, 2005·Journal of Leukocyte Biology·Mario DelgadoDoina Ganea
Jan 13, 2006·European Journal of Immunology·Amelia Fernandez-MartinMario Delgado
Aug 5, 2006·Annals of the New York Academy of Sciences·Seiji ShiodaYoshitaka Kitamura
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Casey M ClementsJenny P-Y Ting
Apr 24, 2007·Journal of Neurochemistry·Katerina K PapachroniVladimir L Buchman
May 29, 2007·Biochemical and Biophysical Research Communications· Bharathi, K S J Rao
Jun 1, 2007·Neurobiology of Aging·Xiaomin SuHoward J Federoff
Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Oct 25, 2007·Biochemical Society Transactions·M L Block, J-S Hong

❮ Previous
Next ❯

Citations

Nov 28, 2019·Cellular and Molecular Neurobiology·Fatemeh SafariFarzaneh Khademi
Oct 16, 2019·Journal of Cellular Physiology·Navid ShomaliSiamak Sandoghchian Shotorbani
Apr 29, 2021·Neural Regeneration Research·Xue ZhangAn-Mu Xie
Jul 13, 2019·Environmental Research·Lilian Calderón-GarcidueñasAngélica González-Maciel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Related Papers

Autoimmunity Reviews
Armando De VirgilioMarco de Vincentiis
Acta Neuropathologica Communications
Antonio Boza-SerranoTomas Deierborg
Current Drug Targets. CNS and Neurological Disorders
S M CardosoC R Oliveira
© 2022 Meta ULC. All rights reserved