Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees

Bio Systems
D K Dunn-WaltersRamit Mehr

Abstract

The immune system learns from its encounters with pathogens and memorizes its experiences. One of the mechanisms it uses for this purpose is the intra-individual evolution of antigen receptors on B lymphocytes, achieved via hypermutation and selection of antigen receptor variable region genes during an immune response. We have developed a novel method for analyzing the graphical properties of phylogenetic trees of receptor genes which have been mutated and selected during an immune response. In the study presented here, we address the artifacts introduced by experimental methods of cell collection for DNA analysis, the meaning of each parameter measured on the tree graphs, and the differences between the dynamics of the humoral immune response in different lymphoid tissues.

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Citations

Jun 24, 2006·Bulletin of Mathematical Biology·Ramit Mehr
Apr 4, 2007·Immunology and Cell Biology·Ravit SaadaRamit Mehr
Aug 12, 2006·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yair HoreshRon Unger
Feb 24, 2009·Seminars in Immunology·Jo SpencerDeborah Dunn-Walters
Aug 19, 2008·Journal of Immunological Methods·Michal BarakRamit Mehr
Sep 16, 2008·European Journal of Immunology·Hilla Tabibian-KeissarIris Barshack
Jan 28, 2010·European Journal of Immunology·Neta S ZuckermanRamit Mehr
Mar 7, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Michelle K ManskeRoshini S Abraham
Jun 27, 2018·Immunological Reviews·Deborah Dunn-WaltersAlex Stewart
Jan 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed UdumanSteven H Kleinstein

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