Immune therapies of autoimmune diseases: are we approaching a real cure?

Current Opinion in Immunology
Lucienne Chatenoud


In developed countries, autoimmune diseases represent the third major cause of morbidity and mortality after cancer and atherosclerosis and their incidence has steadily increased over the past three decades. Conventional therapeutic approaches are essentially palliative, anti-inflammatory or immunosuppressive; in addition, they are non-specific, unrelated to the antigens involved in disease pathogenesis. This explains the growing attention to modern technologies that made new biological agents and methods available. A few of these are already approved for regular clinical practice; others are still in clinical development but hold great promise. The question is: will these new tools allow us to develop a real cure for autoimmunity, restoring self-tolerance to target autoantigens? This goal is ambitious, namely harnessing the pathogenic immune response while preserving the host response to exogenous or unrelated antigens.


Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R O WilliamsR Maini
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Oct 1, 1991·The Journal of Experimental Medicine·A MillerH L Weiner
Jul 26, 1990·The New England Journal of Medicine·P W MathiesonHerman Waldmann
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·R O WilliamsR Maini
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Bach
Sep 24, 1993·Science·D E TrenthamHoward L Weiner
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Daniel, D R Wegmann
Apr 1, 1996·Arthritis and Rheumatism·M L BarnettD E Trentham
Dec 1, 1996·The Journal of Experimental Medicine·L C HarrisonK Takahashi
May 1, 1997·American Journal of Ophthalmology·Robert B NussenblattS M Whitcup
Jul 17, 1997·The New England Journal of Medicine·Larry W MorelandC M Blosch
May 4, 1999·The Journal of Clinical Investigation·J R AbramsS Kang
May 30, 2002·Nature Reviews. Immunology·Marc Feldmann
May 31, 2002·The New England Journal of Medicine·Diabetes Prevention Trial--Type 1 Diabetes Study Group
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Sep 14, 2002·Annals of the Rheumatic Diseases·M J LeandroGeraldine Cambridge
Nov 12, 2002·International Reviews of Immunology·Robert B Nussenblatt
Jan 3, 2003·The New England Journal of Medicine·David H MillerInternational Natalizumab Multiple Sclerosis Trial Group
Feb 4, 2003·Nature Reviews. Immunology·Lucienne Chatenoud
Jun 10, 2003·Arthritis and Rheumatism·Gregg J Silverman, Stuart Weisman
Nov 14, 2003·The New England Journal of Medicine·Joel M KremerLarry W Moreland
Jan 30, 2004·Annual Review of Medicine·William RastetterChristine A White
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Feb 1, 2005·Annals of the New York Academy of Sciences·Berrin Ergun-LongmireNoel K Maclaren
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Oct 11, 2005·Current Opinion in Immunology·Lucienne Chatenoud
Nov 1, 2005·Expert Opinion on Biological Therapy·Philip J Mease
Jan 7, 2006·Annals of the Rheumatic Diseases·Roy FleischmannB Appleton
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanAFFIRM Investigators
Mar 3, 2006·The New England Journal of Medicine·Tarek A YousryDavid B Clifford
Mar 21, 2006·Immunity·Jeffrey A BluestoneLaurence A Turka
Apr 20, 2006·Nature Reviews. Immunology·Jonathan C W Edwards, Geraldine Cambridge
Apr 22, 2006·The Journal of Clinical Investigation·Damien BressonMatthias von Herrath


Sep 8, 2011·Rheumatology International·Ranjana Walker MinzShobha Shegal
Jul 21, 2007·Nature Reviews. Immunology·Lucienne Chatenoud, Jeffrey A Bluestone
Nov 15, 2008·Nature Reviews. Immunology·Rachel R Caspi
Aug 30, 2008·Thyroid : Official Journal of the American Thyroid Association·J Paul BangaLaszlo Hegedus
Nov 4, 2009·Mediators of Inflammation·Manfred Kunz, Saleh M Ibrahim
Sep 30, 2009·BMC Immunology·Wilco de JagerVicki Seyfert-Margolis
Jul 5, 2007·Journal of Zhejiang University. Science. B·H W WitasP Zawicki
Dec 15, 2015·Immunologic Research·Wang-Dong XuYi Liu
Aug 22, 2012·Cytokine & Growth Factor Reviews·Hai-Feng PanDong-Qing Ye
Mar 24, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Eric J Grossman, Rebecca A Shilling
Nov 6, 2008·Rheumatic Diseases Clinics of North America·Nicolas DelaleuRoland Jonsson
Aug 13, 2015·Autoimmunity Reviews·Wang-Dong XuYi Liu
Aug 16, 2015·Autoimmunity Reviews·Antonio Di SabatinoGino Roberto Corazza
Feb 12, 2010·Annals of the New York Academy of Sciences·Yi-chi M KongYaron Tomer
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Gabriel MarceauFernando Alvarez
Apr 7, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Thanh-Huyen TranMansoor Amiji
Sep 13, 2014·Cytokine & Growth Factor Reviews·Hai-Feng PanDong-Qing Ye
Dec 4, 2014·Autoimmunity·Xin-Yu FangDong-Qing Ye
May 20, 2015·Autoimmunity Reviews·Guo-Cui WuDong-Qing Ye
May 18, 2016·Arthritis Research & Therapy·Huan ShiChuangqi Yu
May 20, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Nahideh AsadiAbolfazl Akbarzadeh
May 15, 2015·Journal of Immunology Research·Ebzadrel Carbajal-FrancoGloria Soldevila

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