Immune thrombocytopenia in a patient with COVID-19

International Journal of Hematology
Emilie DeruelleMatthieu Jamme

Abstract

This case report describes immune thrombocytopenic purpura in a 41-year-old man hospitalized in the intensive-care unit for COVID-19, 13 days after the onset of COVID-19 symptoms with respiratory failure at admission. Acute respiratory distress syndrome was treated with, among other drugs, low-molecular-weight heparin. On day 8, his platelet count began descending rapidly. On day 10, heparin treatment was replaced by danaparoid sodium, but by day 13, the continued low platelet count made a diagnosis of heparin-induced thrombocytopenia unlikely. Normocytic nonregenerative anemia gradually developed. On day 13, a bone marrow aspiration showed numerous megakaryocytes and a few signs of hemophagocytosis. Corticosteroids were introduced on day 14, and platelets began rising after 3 days and then fell again on day 19. Intravenous immunoglobulin (IV Ig) was then administered. Two days later, the platelet count returned to normal. The immune cause was confirmed by ruling out the differential diagnoses and the excellent and rapid response to intravenous immunoglobulins. Finally, the patient's respiratory state improved. He was discharged to a respiratory rehabilitation unit on day 38. Our case suggests that an immunological cause should...Continue Reading

References

Dec 13, 2016·Expert Review of Hematology·Massimo FranchiniGiuseppe Lippi
Dec 4, 2019·Blood Advances·Cindy NeunertSara K Vesely
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 18, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiBrandon Michael Henry
Apr 14, 2020·American Journal of Hematology·Evangelos TerposMeletios A Dimopoulos
Apr 16, 2020·The New England Journal of Medicine·Abrar-Ahmad ZulfiqarEmmanuel Andrès
Apr 17, 2020·Annals of Hematology·Panyang XuJiancheng Xu
Apr 18, 2020·Journal of Thrombosis and Haemostasis : JTH·Xiaobo YangYou Shang
May 19, 2020·British Journal of Haematology·Monica LiSita Bushan
May 23, 2020·Pediatrics·Hoi See TsaoDeirdre M Fearon
May 24, 2020·American Journal of Hematology·M W TangB J Biemond
May 24, 2020·Médecine et maladies infectieuses·S HumbertC Chirouze
Jun 5, 2020·Journal of Medical Virology·Ahmet MurtMuhlis Cem Ar
Jun 12, 2020·European Journal of Case Reports in Internal Medicine·Noel Lorenzo-VillalbaEmmanuel Andres
Jun 13, 2020·Annals of Hematology·Michele MerliPaolo Grossi

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Citations

Sep 29, 2020·SN Comprehensive Clinical Medicine·Sukrita Bhattacharjee, Mainak Banerjee
Nov 9, 2020·International Journal of Hematology·Hidesaku Asakura, Haruhiko Ogawa
Feb 27, 2021·Journal of Medical Virology·Josh T GeorgyRamya Iyadurai
Jun 1, 2021·Lupus·Rubén Alonso-BeatoNorberto Ortego Centeno
Jul 6, 2021·Cellular and Molecular Bioengineering·Elisabeth SteadmanWei Yin
Sep 8, 2021·Pediatric Blood & Cancer·Giulia CeglieGiuseppe Palumbo

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Methods Mentioned

BETA
bronchoalveolar lavage
bone marrow aspiration
sedation

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