Immune thrombocytopenia induced by cotrimoxazole

Australian and New Zealand Journal of Medicine
A L Barr, M Whineray

Abstract

Cotrimoxazole administration is occasionally associated with thrombocytopenia. Interference with folate metabolism has been postulated. The drug has also been postulated to induce an autoantibody by acting as a hapten, but proof has not been forthcoming. A case is reported in which the serum has been shown to contain an anti-platelet autoantibody requiring sulphamethoxazole or cotrimoxazole for activity.

References

Jul 1, 1978·The Medical Journal of Australia·E A BlackwellB Bain
Jan 1, 1977·British Journal of Haematology·U M HegdeS Worlledge
Sep 1, 1976·American Journal of Clinical Pathology·T Okuno, D Crockatt

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Citations

Jan 31, 2002·The Annals of Pharmacotherapy·Weeranuj YamreudeewongJanice M Weixelman
Jan 1, 1990·Vox Sanguinis·B GöttscheC Mueller-Eckhardt
Oct 1, 1992·Revista Da Sociedade Brasileira De Medicina Tropical·J W de BarrosP Miki Júnior

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