Abstract
Bone marrow (BM) fibrosis is a potential side effect of thrombopoietin receptor agonist (TPO-RA) treatment. We aimed to investigate stromal seromarker profiles and growth factors in order to elucidate pathogenic and dynamic aspects of immune thrombocytopenia (ITP)-related BM fibrosis before and during TPO-RA treatment. Connective tissue metabolites [procollagen I and III peptides (PINP/PIIINP); hyaluronan (HYA), C-terminal-telopeptide (ICTP), and fibrosis-related growth factors (transforming growth factor-beta (TGF-beta), HGF, basic fibroblast growth factor)] were measured in blood samples acquired before initiation of TPO-RA and subsequently at 6-month intervals for up to 2 years. BM fibrosis was graded MF-0 in 8 (18%), MF-1 30 (65%), and MF-2 8 (18%) in the last available BM biopsy. In the 21 patients having more than one biopsy, the grade of fibrosis from the first to the last available biopsy decreased in 2 (10%), remained unchanged in 15 (71%), and increased in 4 (19%). Pretreatment levels of PIIINP, PINP, ICTP, and HYA were significantly increased in ITP versus controls. PINP, PIIINP, and HYA decreased on TPO-RA; ICTP remained unchanged. PINP:ICTP was lower before and during treatment compared to controls. Pretreatment, T...Continue Reading
References
Jan 1, 1991·American Journal of Hematology·H HasselbalchA Engström Laurent
Feb 1, 1988·Annals of the Rheumatic Diseases·K Hørslev-PetersenI Lorenzen
Nov 1, 1985·Scandinavian Journal of Haematology·H HasselbalchK D Bentsen
Jul 1, 1971·American Journal of Clinical Pathology·D E Bauermeister
Mar 1, 1995·Clinical and Laboratory Haematology·J T ReillyA Smith
Jan 31, 1998·British Journal of Haematology·M YanagidaT Tokiwa
Oct 10, 1998·American Journal of Hematology·P RameshwarP Gascón
Mar 17, 2000·Journal of Gastroenterology and Hepatology·K YamashitaH Tsubouchi
Jun 6, 2002·American Journal of Clinical Pathology·Vonda K DouglasLoAnn C Peterson
Oct 24, 2002·Blood·Hédia ChagraouiFrançoise Wendling
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroJ M Delaissé
Oct 20, 2006·The New England Journal of Medicine·James B BusselJanet L Nichol
Jan 30, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takashi KosoneMasatomo Mori
Jul 10, 2007·Journal of Clinical Immunology·Chengshan GuoMing Hou
Oct 4, 2007·British Journal of Haematology·David J KuterRobert P Hasserjian
Nov 30, 2007·The New England Journal of Medicine·James B BusselJulian M Jenkins
Feb 5, 2008·Lancet·David J KuterJanet L Nichol
May 27, 2009·World Journal of Gastroenterology : WJG·Axel-M GressnerOlav-A Gressner
Aug 13, 2009·Blood·David J KuterMark Rutstein
Jul 14, 2010·Seminars in Hematology·David J Kuter
Jul 14, 2010·Seminars in Hematology·Waleed Ghanima, James B Bussel
Nov 12, 2010·The New England Journal of Medicine·David J KuterDietmar P Berger
Dec 17, 2010·Haematologica·Xingmin FengNeal S Young
Apr 20, 2011·Blood·James B BusselSusie Jun
Aug 16, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leonardo BoiocchiJulia Turbiner Geyer
Sep 10, 2011·British Journal of Haematology·Waleed GhanimaJames B Bussel
Jul 7, 2012·Blood·Nikolaos PapadantonakisKatya Ravid
Jul 14, 2012·Thrombosis Research·Shinya FujitaShosaku Nomura
May 3, 2013·The Journal of Clinical Investigation·Detlef Schuppan, Yong Ook Kim
Jan 28, 2014·Haematologica·Waleed GhanimaJames B Bussel
Mar 22, 2014·Frontiers in Immunology·Aaron C Petrey, Carol A de la Motte
Aug 19, 2014·American Journal of Hematology·William Beau MitchellJames B Bussel
Feb 16, 2015·Haematologica·Muna IraqiBeng H Chong
Mar 25, 2015·American Journal of Hematology·Russell K BrynesKalpana K Bakshi
Jan 21, 2016·British Journal of Haematology·Kay R TingPeter O'Gorman
May 1, 2016·Annals of Hematology·Ann JanssensJanet Franklin