Immune tolerance induction by integrating innate and adaptive immune regulators.

Cell Transplantation
Jun SuzukiZhibin Chen

Abstract

A diversity of immune tolerance mechanisms have evolved to protect normal tissues from immune damage. Immune regulatory cells are critical contributors to peripheral tolerance. These regulatory cells, exemplified by the CD4(+)Foxp3(+) regulatory T (Treg) cells and a recently identified population named myeloid-derived suppressor cells (MDSCs), regulate immune responses and limiting immune-mediated pathology. In a chronic inflammatory setting, such as allograft-directed immunity, there may be a dynamic "cross-talk" between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage. CTLA4-B7-based interaction between the two branches may function as a molecular "bridge" to facilitate such "cross-talk." Understanding the interplays among Treg cells, innate suppressors, and pathogenic effector T (Teff) cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immunosuppressive elements in the innate and adaptive immune system. Successful development of localized strategies of regulatory cell therapies could circumvent the requirement for very high number of cells and decrease the risks associated with systemic immunosuppress...Continue Reading

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Citations

Nov 10, 2013·Immunologic Research·Priyadharshini Devarajan, Zhibin Chen
Aug 2, 2011·Current Opinion in Immunology·Jason R LeesJonathan S Bromberg
Mar 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tao JiangHongchi Jiang
Mar 29, 2014·Frontiers in Immunology·Kevin H Toomer, Zhibin Chen
Apr 5, 2011·Cell Transplantation·Natalia MarekPiotr Trzonkowski
Sep 21, 2011·Cell Transplantation·Xiaojie WangGarth L Warnock

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Methods Mentioned

BETA
antigraft
transgenic
intragraft

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