Immune unresponsiveness of spleen cells from lipopolysaccharide-treated mice to particulate thymus-dependent antigen. I. Evidence for differentiation signal defect

European Journal of Immunology
D PortnoïP Truffa-Bachi

Abstract

The cellular basis of the immune unresponsiveness induced by lipopolysaccharide (LPS) was analyzed at the B and T cell level. The immunosuppressive effect of LPS is not related to altered B cell competence. Inhibition of antibody responses was observed only for thymus-dependent (TD) and not for thymus-independent antigens. In the presence of T cell-replacing factor (TRF), LPS-sensitized B lymphocytes respond to TD antigenic stimulation and differentiate into antibody-forming cells. Evidence is presented for a decreased helper activity of LPS-sensitized T lymphocytes and for a defective production of TRF in concanavalin A-stimulated spleen cells from LPS-treated mice. The implication of a cell compartment other than T is discussed.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S Koenig, M K Hoffmann
Sep 15, 1979·Cellular Immunology·J HumbertP Truffa-Bachi
Jan 1, 1979·Advances in Immunology·D C Morrison, J L Ryan
Feb 28, 1975·Annals of the New York Academy of Sciences·E WeckerL Kühn
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1969·Current Topics in Microbiology and Immunology·E Neter
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

❮ Previous
Next ❯

Citations

Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S D Bilbo, R J Nelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.