PMID: 8937784Nov 1, 1996Paper

Immunhistological evaluation of Creutzfeldt-Jakob disease with reference to the type PrPres deposition

Clinical Neuropathology
J TateishiP Mehraein

Abstract

German patients suspected of having Creutzfeldt-Jakob disease (CJD) and related diseases were studied pathologically. The immunohistochemical findings after hydrolytic autoclaving pretreatment sensitively detected the synaptic-type deposition of the protease-resistant isoform of the prion protein (PrPres which thus served to establish the consensus diagnosis of CJD.

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