PMID: 6103387May 10, 1980Paper

Immunisation with a purified protein from Streptococcus mutans against dental caries in rhesus monkeys

Lancet
T LehnerJ Caldwell

Abstract

A purified protein antigen, molecular weight 185,000, was prepared from Streptococcus mutans and used in the immunisation of monkeys against dental caries. 1 mg of this antigen, mixed with adjuvant and injected subcutaneously, elicited serum IgG and to a lesser extent IgA antibodies. Compared with sham-immunised monkeys, those receiving this antigen had a 70% reduction in dental caries and a smaller growth of Strep. mutans from dental plaque. The results suggest that the defined protein material isolated from Strep. mutans may be one of the antigens eliciting a protective immune response against dental caries. This antigen seems to be a suitable candidate for consideration as a vaccine for man.

References

Nov 1, 1979·Journal of Periodontal Research·C Scully, S J Challacombe
Jan 1, 1977·Archives of Oral Biology·T LehnerS J Challacombe
Apr 1, 1976·Journal of Dental Research·I Van de RijnJ B Zabriskie
May 1, 1975·Archives of Oral Biology·T LehnerJ Caldwell
Dec 27, 1975·British Medical Journal·T Lehner, S J Challacombe
Apr 1, 1976·Journal of Dental Research·T LehnerJ Caldwell
Jan 1, 1976·Journal of Dental Research·G H BowdenE D Fillery

❮ Previous
Next ❯

Citations

May 1, 1987·The Science of the Total Environment·G E Smith
Mar 1, 1985·Vaccine·T Lehner
Jan 13, 2001·Oral Microbiology and Immunology·J S ChiaJ Y Chen
Dec 1, 1992·Oral Microbiology and Immunology·L WiderstromK Hamberg
Apr 22, 2006·Oral Microbiology and Immunology·M A SalamH Senpuku
Jan 1, 1991·Archives of Oral Biology·S J FillerJ R McGhee
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D J Smith
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H F Jenkinson, R J Lamont
Jan 27, 1999·Nature Biotechnology·C G KellyT Lehner
Jul 10, 1986·Nature·M Diesendorf
Jul 27, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ildikó TarIldikó J Márton
May 26, 2010·Molecular Microbiology·L Jeannine BradyHoward F Jenkinson
Jul 22, 2010·Oral Diseases·N S Jakubovics, P E Kolenbrander
Jun 6, 2009·Journal of Dental Research·Y NiuY Li
Sep 14, 2019·Letters in Applied Microbiology·M Patel
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S M Michalek, N K Childers
Jul 1, 1994·Advances in Dental Research·R R Russell
Apr 26, 2002·Vaccine·Toshihiko KogaYoshio Nakano
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·H Marcotte, M C Lavoie
Oct 1, 1993·Infection and Immunity·M NakaiT Koga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.