PMID: 9161467Jan 1, 1997Paper

Immunity aging. I. The chronic perduration of the thymus acute involution at puberty? Or the participation of the lymphoid organs and cells in fatal physiologic decline?

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
G Mathé

Abstract

The author has focused the subject on the perduration of puberty thymus involution as a cause of immunity aging, a term in which he does not include senescence. The decrease between immune reactions against HIV1 at 25 years of age and those at 35 is considerable; the decrease is also indirectly revealed by spontaneous tumor exponentially growing incidence after 40 years in man and its equivalent, 16 months in mice: the immunity parameters indicate a regression correlated with this incidence growth. He regrets the neglect of suppressor cell and anti-idiotype problems by the basic immunologic research. Given the role of cofactors non specifically related to the antigen, such as that CD28 and its ligands, he suggests the interest to approach immunology via the science of chaos and fractals, which would be more appropriate than classical methodology to study highly complex phenomena on which apparently minimal interventions may induce considerable effects.

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Citations

Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G MathéM Bruley-Rosset
Mar 22, 2006·Expert Opinion on Biological Therapy·Antonin BukovskyIrma Virant-Klun
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Antonin BukovskyFei Xu
Jun 30, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Antonin Bukovsky
Jun 27, 2000·Medical Hypotheses·V I Seledtsov, G V Seledtsova
Nov 25, 2003·Microscopy Research and Technique·Rosa M SainzC Rodriguez
Jul 17, 2010·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Antonin Bukovsky
Oct 24, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Ivan VargaStefan Polak
Sep 10, 2019·Aging Cell·Gregory M FahySteve Horvath
Apr 26, 2007·Blood·Valerie P ZediakAvinash Bhandoola
Apr 28, 2020·Acta Paediatrica·Antonio RuggieroAntonio Chiaretti
Jun 3, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tsvetana Ts MarinovaDoychin N Angelov
May 18, 2016·Journal of Forensic Sciences·Samah F IbrahimLaila A Rashed

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