Immunity and immunization of children against diphtheria in Sweden

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
A MarkM Böttiger

Abstract

The level of immunity to diphtheria and the effect of vaccination with different doses of diphtheria toxoid was investigated. The 457 study children, 6, 10 and 16 years of age, had as infants received routine primary vaccination with three doses of diphtheria-tetanus-toxoid or diphtheria-tetanus-pertussis vaccine, and the 16 year-olds also had received a booster dose of tetanus with a small dose of diphtheria at the age of ten. Prior to the study booster, 15% of the 6-year-olds had antitoxin levels against diphtheria less than 0.01 IU/ml, the given minimum level for protection. Of the 10-year-olds, 48% had titres less than 0.01 IU/ml, while the corresponding figure for the 16-year-olds was 24%. After a booster injection of 0.1, 0.25 or 0.5 ml of diphtheria-tetanus vaccine, more than 97% of the children showed titre levels greater than or equal to 0.1 IU/ml, while levels of greater than or equal to 1 IU/ml, indicating titres sufficient for long-term protection, were attained by 23-96%. Systemic reactions were few and moderate. Local reactions were of little clinical significance. In a group of 5-years-olds given diphtheria-tetanus primary vaccinations over wider intervals, only 1.4% had antitoxin titres less than 0.01 IU/ml. The...Continue Reading

References

Jan 7, 1988·The New England Journal of Medicine·R RappuoliE Falsen
Jan 7, 1988·The New England Journal of Medicine·D T Karzon, K M Edwards
Apr 1, 1987·Journal of Biological Standardization·K LarsenB Hederstedt
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·B Christenson, M Böttiger
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·B BjörkholmL Hagberg
Dec 13, 1974·Deutsche medizinische Wochenschrift·B StallkampL C Tung
Nov 19, 1982·Deutsche medizinische Wochenschrift·H Allerdist, J Ehrengut-Lange
Apr 1, 1952·American Journal of Public Health and the Nation's Health·G EDSALL

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Citations

Apr 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T LagergårdJ Taranger
Aug 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B BjörkholmL Hagberg
Mar 1, 2012·Epidemiology and Infection·P di GiovineC von Hunolstein
May 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A MarkM Granström
Jan 1, 1991·Scandinavian Journal of Infectious Diseases·B Christenson, M Böttiger
Aug 17, 2002·The Pediatric Infectious Disease Journal·Rose-Marie CarlssonClaus Lundin
Apr 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M T LongT E Lock
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·M Böttiger, G Pettersson

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