PMID: 8940965Nov 1, 1996Paper

Immunity and morbidity in schistosomiasis japonicum infection

The American Journal of Tropical Medicine and Hygiene
G R OldsB Blas

Abstract

Schistosomiasis japonica differs significantly from Schistosoma mansoni infection in several epidemiologic, immunologic, and operational characteristics for control. Because of numerous nonhuman hosts, transmission remains high despite aggressive case finding and treatment of human cases. Diagnosis of infection using the Kato-Katz stool technique is less sensitive and specific in this than in other species of human schistosomes, making case finding and treatment a less effective approach to control. Clinically, morbidity induced by S. japonicum appears unrelated to intensity of infection, and is more severe than that of S. mansoni in terms of liver pathology and stunting of child growth and development. Both hepatic enlargement and fibrosis appear to be reversible and preventable with aggressive treatment but several operational characteristics for control of infection due to S. japonicum make the community impact of case-finding and treatment with praziquantel less pronounced than would have been predicted by the analysis of individual cases. In the Philippines, rebound morbidity following reinfection mandates short treatment intervals between screening and treatment to have a significant impact on morbidity, while in China in...Continue Reading

Citations

Dec 21, 2005·The Journal of Nutrition·Hannah M CoutinhoJennifer F Friedman
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M FitzpatrickKarl F Hoffmann
Feb 15, 2001·Current Infectious Disease Reports·G. Richard Olds, Srinivasan Dasarathy
Apr 19, 2002·The New England Journal of Medicine·Allen G P RossDonald P McManus
Jun 5, 2008·PLoS Neglected Tropical Diseases·Amara E EzeamamaJennifer F Friedman
May 18, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G Richard Olds
Aug 23, 2006·Infection and Immunity·Tjalling LeenstraJennifer F Friedman
Dec 3, 1999·Parasite Immunology·M G HernandezM L Santiago
Jul 27, 2001·Current Gastroenterology Reports·T W Schafer, B R Hale
Oct 27, 2016·Current Opinion in Infectious Diseases·David U OlvedaAllen G P Ross
Sep 15, 2000·Infectious Disease Clinics of North America·I BicaM J Stadecker

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