PMID: 1200844Jan 1, 1975Paper

Immunity following intranasal administration of an inactivated, freeze-dried A/England/42/72 vaccine

Archives of Virology
C W PotterA Clarke

Abstract

A group of 23 student volunteers were each inoculated intranasally with 400 IU of inactivated, freeze-dried A/England/42/72 vaccine. Only one volunteer showed a four-fold rise in serum HI antibody following immunization, and the mean increase in serum HI antibody (gmt) for all volunteers did not increase two-fold. Thirteen of the volunteers developed detectable levels of nasal wash neutralizing antibody after immunization; local antibody was most commonly found in volunteers who produced a detectable but less than four-fold fise in serum antibody titre, and who produced nasal washings with relatively high concentrations of protein and secretory IgA. Four weeks after immunization, the vaccinees and a matched group of control subjects were inoculated with attenuated A/England/42/72 (MRC-7) virus. Evidence of infection was found in 14 of 23 (61 per cent) of control subjects and in seven of 23 (30 per cent) of immunized volunteers. This result showed a significant protection (P = 0.04) against challenge virus infection for volunteers given intranasal vaccine.

References

Oct 1, 1973·The Journal of the Society of Occupational Medicine·W Haigh, R W Howell
Nov 24, 1966·The New England Journal of Medicine·C B SmithR M Chanock
Oct 1, 1969·American Journal of Epidemiology·J C PerkinsR M Chanock
Sep 1, 1972·The Journal of Infectious Diseases·R H Waldman, W J Coggins
Mar 1, 1973·Postgraduate Medical Journal·K S LienR V Strik
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1971·American Journal of Epidemiology·J M GwaltneyP W White
Jan 20, 1969·JAMA : the Journal of the American Medical Association·R H WaldmanP A Small
Sep 1, 1958·The Journal of Hygiene·S F DE ST GROTHK J LAFFERTY
Sep 1, 1949·American Journal of Diseases of Children·J J QUILLIGANE MINUSE

❮ Previous
Next ❯

Citations

Dec 1, 1976·Medical Microbiology and Immunology·R JenningsC W Potter
May 27, 2005·Vaccine·Robert C ReadRoy Jennings
Jun 1, 1976·Postgraduate Medical Journal·D A Tyrrell
Feb 22, 2007·Plastic and Reconstructive Surgery·Bibiana KotrikovaJoachim Mühling
Nov 3, 2010·Critical Care Medicine·Jan Gralton, Mary-Louise McLaws

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.