PMID: 2101466Sep 1, 1990Paper

Immunity induced by live attenuated Salmonella vaccines

Research in Microbiology
C E HormaecheB A Stocker

Abstract

Studies on the degree and specificity of protection conferred by immunization with aroA salmonella live vaccines in BALB/c mice are described. Animals were immunized i.v. and challenged orally 3 months later to ensure that the vaccine had been cleared from the tissues. Vaccination with Salmonella typhimurium aroA SL3261 conferred very good protection against virulent S. typhimurium C5 (over 10,000 x LD50). The specificity of cross protection was studied using S. typhimurium, Salmonella enteritidis and Salmonella dublin for vaccination and challenge, including challenge with variants of S. typhimurium and S. enteritidis of similar virulence which differed in the main LPS (lipopolysaccharide) antigen (0-4 or 0-9). S. typhimurium SL3261 gave very good protection against S. typhimurium C5 (0-4), but no protection against S. enteritidis Se795 (0-9). However, challenge with strains differing in the main 0 antigens showed that, although protection was generally better to strains expressing the same LPS type as the vaccine, specificity of protection was determined more by the background (S. typhimurium or S. enteritidis) of the parent strain used for the challenge than by 0 factors 4 or 9, suggesting that other factors could be involve...Continue Reading

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Citations

Jan 1, 1994·International Journal of Technology Assessment in Health Care·J J Mekalanos
Jul 19, 2000·The Journal of Experimental Medicine·D M MonackS Falkow
Jun 14, 2015·International Journal of Medical Microbiology : IJMM·Dacie R BridgeD Scott Merrell
Apr 21, 2016·Fish & Shellfish Immunology·Ilhan AltinokErol Capkin
Feb 5, 2005·Anais Da Academia Brasileira De Ciências·Luís C S FerreiraWolfgang Schumann
Dec 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanna A WroblewskaYang-Xin Fu
Jan 30, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B Gunasekaran, K M Gothandam

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