Immunity, microbiota and kidney disease

Nature Reviews. Nephrology
Felix KnaufRichard A Flavell

Abstract

The recognition that intestinal microbiota exert profound effects on human health has led to major advances in our understanding of disease processes. Studies over the past 20 years have shown that host components, including components of the host immune system, shape the microbial community. Pathogenic alterations in commensal microorganisms contribute to disease manifestations that are generally considered to be noncommunicable, such as inflammatory bowel disease, diabetes mellitus and liver disease, through a variety of mechanisms, including effects on host immunity. More recent studies have shed new light on how the immune system and microbiota might also drive the pathogenesis of renal disorders. In this Review, we discuss the latest insights into the mechanisms regulating the microbiome composition, with a focus both on genetics and environmental factors, and describe how commensal microorganisms calibrate innate and adaptive immune responses to affect the activation threshold for pathogenic stimulations. We discuss the mechanisms that lead to intestinal epithelial barrier inflammation and the relevance of certain bacteria to the pathogenesis of two common kidney-based disorders: hypertension and renal stone disease. Limi...Continue Reading

References

Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Sep 1, 1986·The Journal of Nutrition·T Høverstad, T Midtvedt
Oct 1, 1971·The Journal of Experimental Medicine·S Baez, H A Gordon
Jan 1, 1995·Gut·I A FinnieJ M Rhodes
Dec 10, 1999·Journal of the American College of Cardiology·C J WiedermannJ Willeit
Dec 1, 2000·Scandinavian Journal of Gastroenterology·A VenkatramanS Murthy
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AtumaL Holm
Jun 1, 2001·Inflammatory Bowel Diseases·G C SturnioloR D'Incà
Nov 6, 2001·The Journal of Biological Chemistry·Rao S KoduriMichael H Gelb
May 29, 2002·The Journal of Laboratory and Clinical Medicine·Giacomo Carlo SturnioloRenata D'inca
Aug 23, 2002·The American Journal of Gastroenterology·Peter SuenaertPaul Rutgeerts
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Jan 28, 2003·Nature Immunology·Lora V HooperJeffrey I Gordon
Mar 19, 2003·European Journal of Clinical Investigation·P VerniaUNKNOWN Gruppo Italiano per lo Studio del Colon and del Retto
May 8, 1959·Annals of the New York Academy of Sciences·H A GORDON
Feb 10, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas Y MaHamid M Said
Jul 28, 2004·The American Journal of Pathology·Cristiano RumioAndrea Balsari
May 24, 2005·Nature Immunology·Michael E Selsted, Andre J Ouellette
Jun 24, 2005·Inflammatory Bowel Diseases·Peter SuenaertPaul Rutgeerts
Dec 24, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert W FreelManoocher Soleimani
Mar 15, 2006·Nature Genetics·Zhirong JiangPeter S Aronson
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Aug 26, 2006·Science·Heather L CashLora V Hooper
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·David S GoldfarbJohn R Asplin
Sep 14, 2007·Seminars in Immunopathology·Jonathan BarrattJohn Feehally
Nov 28, 2007·The Journal of Experimental Medicine·Mike G LaukoetterCharles A Parkos
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rana Al-SadiThomas Y Ma
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Jun 28, 2008·Scandinavian Journal of Gastroenterology·Eduardo Garcia VilelaAloísio Sales Da Cunha
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Malin E V JohanssonGunnar C Hansson
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shipra VaishnavaLora V Hooper
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman

❮ Previous
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Citations

Oct 4, 2019·Der Internist·T SpeerD Fliser
Aug 14, 2020·Channels·Naghmeh Hassanzadeh KhayyatOleh Pochynyuk
Apr 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Preeti PathakJ Mark Brown
May 2, 2019·Frontiers in Immunology·Ning SongLinlin Guo
Oct 13, 2020·Renal Failure·Balamurugan PackialakshmiXiaoming Zhou
Nov 22, 2020·Journal of Cancer Research and Clinical Oncology·Junpeng WangTianzhong Yan
Dec 31, 2020·Herz·Stefan J SchunkDanilo Fliser
Jul 27, 2021·Frontiers in Cellular and Infection Microbiology·Yangyang LiYongqi Liu
Jul 28, 2021·Scientific Reports·Signe Abitz WintherPeter Rossing
Jul 9, 2021·Kidney Research and Clinical Practice·Myung-Gyu KimSang-Kyung Jo
Sep 13, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paul GabarreJérôme Tourret
Jan 27, 2022·Current Nutrition Reports·Baris AfsarMehmet Kanbay

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Methods Mentioned

BETA
histone acetylation
metabolomics profiling
fluorescence-activated cell sorting

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