Immunity to Brugia pahangi in athymic nude and normal mice: eosinophilia, antibody and hypersensitivity responses

Parasite Immunology
A C Vickery, A L Vincent

Abstract

Congenitally athymic nude (nu/nu) mice, immunologically reconstituted by thymus grafting before inoculation with infective larvae, and mice heterozygous for the nu gene (nu/+), mounted potent protective humoral and cellular immune responses to Brugia pahangi. Although responses were not identical, both groups of mice produced IgM, IgG and IgE antibodies specific for adult worm antigen (S-Ag) present in a crude aqueous extract, made immediate and delayed hypersensitivity footpad swelling responses when challenged with S-Ag and eliminated their infection in the early larval stages. Heterozygotes also exhibited a marked eosinophilia which peaked coincident with larval killing. In contrast, thymus grafting of patent nudes had no effect upon microfilaraemias or adult worm burdens and did not completely protect against a challenge larval inoculum although antibodies specific for S-Ag were produced. With the occasional exceptions of moderate immediate footpad swelling and very low titres of IgM specific for S-Ag, no specific immune responses to B. pahangi were found in ungrafted nude mice which allowed full development of adult worms and supported patent infections.

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Citations

Oct 1, 1988·Immunology and Cell Biology·G R RajasekariahD Subrahmanyam
Mar 1, 1991·The Journal of Experimental Medicine·F K NelsonT V Rajan
Jul 11, 2014·PLoS Neglected Tropical Diseases·Tiffany WeinkopffPatrick Lammie

Related Concepts

Metazoa
Antibody Formation
Brugia
Concanavalin A
Crosses, Genetic
Enzyme-Linked Immunosorbent Assay
Filariasis
Genetic Carriers
Allergic Reaction
IgG2B

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