PMID: 6970898Mar 12, 1981Paper

Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse

Nature
J L Grun, W P Weidanz

Abstract

Immunity to malaria has a multicomponent basis which requires the participation of both T- and B-lymphocyte systems. Previous studies have suggested that the T-lymphocyte system has an essential role in 're-infection immunity' to malaria, but that B cells and/or their products are necessary for the host to survive acute infection and to clear the blood of parasites during chronic malaria. Thus, B-cell-deficient mice and chickens died of fulminant malaria when infected with Plasmodium yoelii and Plasmodium gallinaceum, respectively, but when their acute infections were controlled with subcurative chemotherapy, B-cell-deficient host developed chronic low-grade infections and resisted challenge with homologous parasites. In contrast, athymic nude mice failed to control their endogenous P. yoelii infection after the termination of drug therapy unless they had been thymus grafted before initiation of acute infection. We now report that Plasmodium chabaudi adami (556KA) infection in B-cell-deficient mice results in an activation of a T-cell-dependent immune mechanism which terminates acute malaria in a similar way to that seen in immunologically intact mice. Furthermore, these immunized B-cell-deficient mice were resistant to homolog...Continue Reading

References

Jan 1, 1979·The American Journal of Tropical Medicine and Hygiene·D W Roberts, W P Weidanz
Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·A C Allison, I A Clark
Jun 1, 1979·The Journal of Experimental Medicine·H L ShearC Bianco
Feb 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·R G RankA Bondi
Apr 1, 1976·The Journal of Experimental Medicine·J M DwyerS Lewis

❮ Previous
Next ❯

Citations

Jan 1, 1985·Immunology Letters·J H PlayfairJ Taverne
Oct 1, 1987·Parasitology Today·I A Clark
Nov 1, 1993·Parasitology Today·S L Stanley, H W Virgin
Mar 1, 1993·Parasitology Today·A Taylor-Robinson
Sep 1, 1995·Parasitology Today·A W Taylor-Robinson
Nov 18, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Pramatha R BhattacharyaC R Pillai
Dec 25, 1982·Lancet·A C Allison, E M Eugui
Jul 1, 1994·Research in Immunology·T von der WeidJ Langhorne
Jul 1, 1994·Research in Immunology·G E Grau, C Behr
Jan 1, 1989·Parasitology·G H Mitchell
Apr 21, 1983·The New England Journal of Medicine·D J Wyler
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M LewM Sheppard
Nov 10, 2010·International Immunology·Daisuke KimuraKatsuyuki Yui
Dec 1, 1989·Immunological Reviews·J LanghorneS S Gillard
Jan 1, 1989·Annals of the New York Academy of Sciences·L H Miller
Jul 21, 1998·Annals of the New York Academy of Sciences·W L GoffC W Cluff
Jul 28, 2010·Infection and Immunity·William P WeidanzHenri C van der Heyde
May 23, 1998·Annual Review of Immunology·M F GoodL H Miller
Jul 13, 2007·Current Opinion in Immunology·Ian A Cockburn, Fidel Zavala
Aug 13, 2009·European Journal of Immunology·Michelle N Wykes, Michael F Good
Jan 26, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Henri C van der HeydeJohn P Nolan
Feb 28, 2007·Cellular Microbiology·Daniel CarapauAna Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.