Immunity to SARS-CoV-2: Lessons Learned.

Frontiers in Immunology
Jaime Fergie, Amit Srivastava


In the year since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and with understanding of the etiology of the coronavirus disease 2019 (COVID-19) pandemic, it has become clear that most infected individuals achieve some form of immunity against the virus with relatively few reported reinfections. A number of vaccines have already achieved emergency use authorization based on data from large phase 3 field efficacy clinical trials. However, our knowledge about the extent and durability of this immunity, and the breadth of vaccine coverage against SARS-CoV-2 variants is still evolving. In this narrative review, we summarize the latest and rapidly developing understanding of immunity to SARS-CoV-2 infection, including what we have learned about the key antigens of SARS-CoV-2 (i.e., the spike protein and its receptor-binding domain), their importance in vaccine development, the immediate immune response to SARS-CoV-2, breadth of coverage of emerging SARS-CoV-2 variants, contributions of preexisting immunity to related coronaviruses, and duration of immunity. We also discuss lessons from newer approaches, such as systems serology, that provide insights into molecular and cellular immune responses elici...Continue Reading


Feb 9, 2008·Emerging Infectious Diseases·Li-Ping WuGuo-Dong Liang
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Jun 23, 2016·Emerging Infectious Diseases·Daniel C PayneMohammad Mousa Al Abdallat
Apr 8, 2020·Immunity·Fatima Amanat, Florian Krammer
Apr 11, 2020·Nature Reviews. Drug Discovery·Tung Thanh LeStephen Mayhew
May 12, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nisha S MehtaJonathan S Nguyen-Van-Tam
May 16, 2020·Indian Journal of Pediatrics·Nitin DhochakRakesh Lodha
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Mehul S SutharJens Wrammert
Jun 17, 2020·JAMA : the Journal of the American Medical Association·Mary MarovichMyron S Cohen
Jun 20, 2020·Nature·Davide F RobbianiMichel C Nussenzweig
Jul 6, 2020·Emerging Infectious Diseases·Jinzhi GaoLing Chen
Jul 9, 2020·Nature Reviews. Immunology·Alessandro Sette, Shane Crotty
Jul 13, 2020·Paediatric Respiratory Reviews·Archana KoiralaPhilip N Britton
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 17, 2020·Science Immunology·Leticia Kuri-CervantesMichael R Betts
Jul 28, 2020·Nature·Carolina LucasAkiko Iwasaki
Jul 30, 2020·The New England Journal of Medicine·Kizzmekia S CorbettBarney S Graham
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster
Aug 4, 2020·BioRxiv : the Preprint Server for Biology·Rachael A MansbachS Gnanakaran
Aug 7, 2020·Current Opinion in Immunology·Carolin LoosGalit Alter
Aug 14, 2020·Immunity·Caroline AtyeoGalit Alter
Aug 19, 2020·Nature·Stanley Perlman
Aug 23, 2020·Science Immunology·Christopher MaucourantUNKNOWN Karolinska COVID-19 Study Group
Sep 2, 2020·The New England Journal of Medicine·Daniel F GudbjartssonKari Stefansson
Sep 4, 2020·MSphere·Carolin LoosGalit Alter
Sep 12, 2020·JAMA : the Journal of the American Medical Association·David S Stephens, M Juliana McElrath
Sep 16, 2020·Nature Medicine·Arthur W D EdridgeLia van der Hoek
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jason W RauschMary F Kearney
Sep 24, 2020·Nature·Florian Krammer
Sep 30, 2020·The New England Journal of Medicine·Evan J AndersonUNKNOWN mRNA-1273 Study Group
Oct 1, 2020·MedRxiv : the Preprint Server for Health Sciences·Ryan M PaceMichelle K McGuire
Oct 1, 2020·The Journal of Clinical Investigation·Manish SagarJoseph P Mizgerd

❮ Previous
Next ❯


Apr 27, 2021·Anaesthesia Critical Care & Pain Medicine·Sacha RozencwajgUNKNOWN Social Media Team of Accpm
May 5, 2021·Anaesthesia Critical Care & Pain Medicine·Sacha RozencwajgMarc-Olivier Fischer

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.