Abstract
Trypanosoma cruzi, the causative agent of Chagas' disease, infects humans and animals in tropical, subtropical and some temperature regions of the western hemisphere. At present, there is no effective vaccine for T. cruzi infection. Glucan, a beta-1,3 polyglucose biological response modifier, possesses significant adjuvant activity. The present study investigated the adjuvant activity of particulate glucan when combined with a vaccine of glutaraldehyde-killed T. cruzi culture forms. ICR/HSD mice (20 g) were injected s.c. with glutaraldehyde-killed T. cruzi on days 21, 14 and 7 prior to challenge with 50 T. cruzi blood forms. Particulate glucan (1 mg/mouse) was administered s.c. either alone or in conjunction with T. cruzi vaccine. Isovolumetric dextrose served as control. Dextrose, glucan or T. cruzi vaccine as single treatment regimens showed 100% mortality with 20.5, 21.4 and 21.6 day median survival times, respectively. In contrast, glucan administered with T. cruzi vaccine showed an 85% (P less than 0.01) survival at 275 days post-challenge. In addition, the number of T. cruzi observed in the blood of glucan--T. cruzi immunized mice was lower than the appropriate controls. However, immunized mice which survived at 275 days ...Continue Reading
References
Feb 1, 1979·Parasitology·R Bomford, N McHardy
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·N R Di LuzioA Kitahama
Mar 1, 1975·Journal of the National Cancer Institute·P W MansellN R Di Luzio
Jan 1, 1988·The Journal of Surgical Research·D L WilliamsN R Di Luzio
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L WilliamsN R Di Luzio
Jan 1, 1987·International Journal of Immunopharmacology·E R SherwoodN R Di Luzio
Jan 1, 1987·American Journal of Surgery·I W BrowderN DiLuzio
Jul 1, 1984·Parasite Immunology·A HaqS Ahmad
Jan 1, 1984·International Journal of Immunopharmacology·A SharmaS Ahmad
Jan 1, 1984·International Archives of Allergy and Applied Immunology·M T ScottL Chedid
Citations
Jan 1, 1992·Folia Microbiologica·J FranĕkH Krátká
Aug 5, 2008·Applied Microbiology and Biotechnology·Vanessa K BernerKenneth W Hunter
Mar 1, 1997·International Journal for Parasitology·C H YunB Laarveld
Aug 10, 2000·Vaccine·R S Corral, P B Petray
Apr 12, 2008·Natural Product Research·Hojjatollah ShokriAli Reza Khosravi
May 15, 2013·Diseases of Aquatic Organisms·V Thanga VijiT Citarasu
May 24, 2011·World Journal of Clinical Oncology·Vaclav Vetvicka
May 17, 2014·Fish & Shellfish Immunology·Ju-Won KimChan-Il Park
Dec 26, 2009·Veterinary Immunology and Immunopathology·Eva SonckEric Cox
Nov 10, 2015·Cellular Immunology·Vanessa K BernerKenneth W Hunter
Dec 6, 2005·Fish & Shellfish Immunology·Wei-Hua Chu
Dec 25, 2012·International Immunopharmacology·Wei ZhuSixiang Zou
Feb 19, 2003·FEMS Immunology and Medical Microbiology·Cheol-Heui YunBernard Laarveld
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vaclav VetvickaJosef Richter
Apr 3, 2008·Journal of Immunotoxicology·M Novak, V Vetvicka
Mar 3, 2010·Expert Review of Anti-infective Therapy·Iain J ThompsonDiane E Williamson
Sep 24, 2019·Scandinavian Journal of Immunology·Vaclav VetvickaPetr Sima
Dec 25, 2009·Clinical and Vaccine Immunology : CVI·E StuyvenE Cox
Aug 16, 2006·Journal of Animal Science·J LiC H Lai
May 1, 2020·Frontiers in Chemistry·Shuyao Lang, Xuefei Huang
Aug 11, 2019·Clinical and Experimental Immunology·A AbrahamP C F Oyston
Nov 1, 1991·Journal of Clinical Microbiology·P F Roslansky, T J Novitsky