PMID: 2506140Jan 1, 1989Paper

Immunization against Trypanosoma cruzi: adjuvant effect of glucan

International Journal of Immunopharmacology
D L WilliamsE L Jones

Abstract

Trypanosoma cruzi, the causative agent of Chagas' disease, infects humans and animals in tropical, subtropical and some temperature regions of the western hemisphere. At present, there is no effective vaccine for T. cruzi infection. Glucan, a beta-1,3 polyglucose biological response modifier, possesses significant adjuvant activity. The present study investigated the adjuvant activity of particulate glucan when combined with a vaccine of glutaraldehyde-killed T. cruzi culture forms. ICR/HSD mice (20 g) were injected s.c. with glutaraldehyde-killed T. cruzi on days 21, 14 and 7 prior to challenge with 50 T. cruzi blood forms. Particulate glucan (1 mg/mouse) was administered s.c. either alone or in conjunction with T. cruzi vaccine. Isovolumetric dextrose served as control. Dextrose, glucan or T. cruzi vaccine as single treatment regimens showed 100% mortality with 20.5, 21.4 and 21.6 day median survival times, respectively. In contrast, glucan administered with T. cruzi vaccine showed an 85% (P less than 0.01) survival at 275 days post-challenge. In addition, the number of T. cruzi observed in the blood of glucan--T. cruzi immunized mice was lower than the appropriate controls. However, immunized mice which survived at 275 days ...Continue Reading

References

Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·N R Di LuzioA Kitahama
Mar 1, 1975·Journal of the National Cancer Institute·P W MansellN R Di Luzio
Jan 1, 1988·The Journal of Surgical Research·D L WilliamsN R Di Luzio
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L WilliamsN R Di Luzio
Jan 1, 1987·International Journal of Immunopharmacology·E R SherwoodN R Di Luzio
Jan 1, 1987·American Journal of Surgery·I W BrowderN DiLuzio
Jan 1, 1984·International Journal of Immunopharmacology·A SharmaS Ahmad
Jan 1, 1984·International Archives of Allergy and Applied Immunology·M T ScottL Chedid

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