Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge.

Journal for Immunotherapy of Cancer
Bruno AlickeStephen E Gould

Abstract

The recent success of multiple immunomodulating drugs in oncology highlights the potential of relieving immunosuppression by directly engaging the immune system in the tumor bed to target cancer cells. Durable responses to immune checkpoint inhibitors experienced by some patients may be indicative of the formation of a T cell memory response. This has prompted the search for preclinical evidence of therapy-induced long-term immunity as part of the evaluation of novel therapeutics. A common preclinical method used to document long-term immunity is the use of tumor rechallenge experiments in which tumor growth is assessed in mice that have previously rejected tumors in response to therapy. Failure of rechallenge engraftment, typically alongside successful engraftment of the same tumor in naive animals as a control, is often presented as evidence of therapy-induced tumor immunity. Here, we present evidence that formation of tumor immunity often develops independent of therapy. We observed elevated rates of rechallenge rejection following surgical resection of primary tumors for four of five commonly used models and that such postexcision immunity could be adoptively transferred to treatment-naïve mice. We also show that tumor-spec...Continue Reading

References

Dec 1, 1975·Cancer·D P Griswold, T H Corbett
Jan 1, 1987·Cancer Immunology, Immunotherapy : CII·P M CaponeT M Chu
Jan 1, 1983·Advances in Cancer Research·E Gorelik
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincenzo BrontePaola Zanovello
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Mar 2, 2012·Nature Reviews. Cancer·Thomas BlankensteinElizabeth M Jaffee
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
Mar 24, 2018·Science·Antoni Ribas, Jedd D Wolchok
Jan 16, 2020·The Journal of Experimental Medicine·Aude-Hélène CapiettoLélia Delamarre

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
flow cytometry

Software Mentioned

FlowJo

Related Concepts

Related Feeds

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.

Related Papers

Cancer Immunology, Immunotherapy : CII
A Nazmul H KhanThomas B Tomasi
Drug Safety : an International Journal of Medical Toxicology and Drug Experience
A L Po, M J Kendall
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Christine M HuntArie Regev
© 2021 Meta ULC. All rights reserved