PMID: 39663Oct 26, 1979

Immunization of adult rats against 2.5 S NGF: effects on the peripheral sympathetic nervous system

Brain Research
U OttenJ Thibault

Abstract

The biochemical and morphological changes effected by immunization of adult rats with 2.5 S mouse nerve growth factor (NGF) were studied in sympathetic ganglia and in representative target organs. This immunization procedure maintains high levels of circulating anti NGF-antibody for periods of months. Morphological analysis revealed a general reduction in the size of the adrenergic neurons in the superior cervical ganglion (SCG) which was also reflected at the biochemical level by a 30% decrease in total protein content and a 50--60% reduction in the total activities of all norepinephrine-synthesizing enzymes. However, there was no change in total choline acetyltransferase activity. The biochemical and morphological changes observed in the SCG seem to be confined to the neuronal cell body, since at any stage of immunization target organs (the submandibular and the pineal gland) remained unaffected. All sympathetic ganglia investigated--except the superior mesenteric ganglion--responded in a similar way to the immunization against 2.5 S NGF. These changes in the adrenergic cell bodies were largely reversible. The recovery of normal enzyme activities followed closely the decrease of the antibody titer after cessation of immunizat...Continue Reading

References

Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
Jan 1, 1970·Pneumonologie. Pneumonology·A LindO Ouchterlony
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenR Kettler
Mar 1, 1970·Experimental Cell Research·E L Fenton
Jul 7, 1967·Biochemical Pharmacology·M LevittS Udenfriend

Citations

Jul 29, 1982·Brain Research·J P SchwartzE M Johnson
May 20, 1982·Brain Research·E M JohnsonJ Pearson
Dec 1, 1988·Brain Research. Developmental Brain Research·C R BuckI B Black
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jun 29, 2013·Cell Death & Disease·A J KoleM Deshmukh
Feb 1, 1994·Journal of Autonomic Pharmacology·R Chess-WilliamsG P Reynolds
Jul 24, 2001·The Journal of Hand Surgery·G S KrygerH J Buncke
Jan 1, 1980·Journal of Neurochemistry·G P Harper, H Thoenen
Jun 30, 2006·Journal of Neurochemistry·W Bradley JacobsFreda D Miller
Sep 11, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·W Bradley JacobsFreda D Miller
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S B McMahon
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Feb 8, 1987·The Journal of Comparative Neurology·G RaivichA Sutter

Related Concepts

Choline O-Acetyltransferase
Dopamine-beta-monooxygenase
Sympathetic Ganglia
Immunodiffusion Measurement
Neurite Outgrowth Factors
Nerve Tissue Proteins
Neurons
Norepinephrine, (+, -)-Isomer
Pineal Gland
Submandibular Gland

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.