PMID: 9423884Jan 10, 1998Paper

Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection

Infection and Immunity
Clemens H M KockenA W Thomas

Abstract

Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.

References

Sep 1, 1988·Molecular and Biochemical Parasitology·D J BzikJ Inselburg
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T E Wellems, R J Howard
Aug 1, 1994·The American Journal of Tropical Medicine and Hygiene·W E CollinsC L Morris

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