PMID: 3770268Jan 1, 1986Paper

Immunization of carp (Cyprinus carpio) with a Vibrio anguillarum bacterin: indications for a common mucosal immune system

Developmental and Comparative Immunology
J W RomboutE Egberts

Abstract

Uptake and transport of formalin-killed Vibrio anguillarum bacteria were studied in the second gut segment of carp and the resulting reaction of the immune system was investigated. Within a few hours after anal administration antigenic determinants of bacteria were present in intraepithelial macrophages of the second gut segment. In gut and skin mucus and bile, immunoglobulins (Ig's) were detected, but the amount was much lower than found in serum. In mucus of the second gut segment, 4 times more Ig (per mg protein) was found than in the first segment. Upon oral or anal immunization, slightly enhanced antigen-specific Ig titers could be detected in skin mucus and bile, but only after a booster along the same route. The existence of a common mucosal immune system is discussed, with special reference to the significance of the second gut segment. After anal intubation an increase of antigen-specific Ig could also be observed in serum. Following a booster, an enhanced cal memory. After anal boosting equal levels of serum antibody were reached compared with two consecutive intramuscular injections. However, no significant antibody increase occurred in serum after oral immunization, not even when bacteria were administered daily wit...Continue Reading

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Citations

Dec 6, 2005·Anatomy and Embryology·Heidi B T HuttenhuisJan H W M Rombout
Jan 1, 1987·Developmental and Comparative Immunology·C J Lobb
Jan 1, 1988·Developmental and Comparative Immunology·S HartT H Grayson
Jan 1, 1993·Developmental and Comparative Immunology·J H RomboutM I Villena
May 1, 1991·Research in Immunology·W B Van MuiswinkelJ H Rombout
Jan 1, 1995·The British Veterinary Journal·C M Press, A Lillehaug
Nov 7, 2001·Developmental and Comparative Immunology·Lars Pilström
Jul 13, 1999·Developmental and Comparative Immunology·H WidholmL Pilström
Jan 15, 2014·Fish & Shellfish Immunology·Francisco A GuardiolaMaría A Esteban
May 14, 2014·Fish & Shellfish Immunology·Maria Rosaria CosciaChiara Maria Motta
Feb 14, 2016·Developmental and Comparative Immunology·Guro Løkka, Erling Olaf Koppang
Dec 5, 2012·Veterinary Immunology and Immunopathology·Victoria A Valdenegro-VegaBarbara F Nowak
Dec 3, 2011·Developmental and Comparative Immunology·Irene SalinasJ Oriol Sunyer
Sep 14, 2010·Fish & Shellfish Immunology·Jan H W M RomboutViswanath Kiron
Mar 29, 2016·Developmental and Comparative Immunology·Carmen W E Embregts, Maria Forlenza
Sep 27, 2005·Fish & Shellfish Immunology·Allan G Petrie, Anthony E Ellis
Aug 9, 2005·Developmental and Comparative Immunology·Stein Tore Solem, Jørgen Stenvik
Jun 28, 2014·Fish & Shellfish Immunology·Francisco A GuardiolaMaría A Esteban
Aug 26, 2014·Fish & Shellfish Immunology·Jan H W M RomboutViswanath Kiron
Nov 24, 2016·Biology·Sara Mashoof, Michael F Criscitiello
Oct 12, 2004·Fish & Shellfish Immunology·Stefaan VervarckeArmand Michoel
Oct 1, 1995·The Journal of Applied Bacteriology·T TiainenJ L Larsen
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Joanne L Maki, Harry W Dickerson
Feb 7, 2015·PloS One·Maki OhtaniMartin Kristian Raida
May 16, 2019·Journal of Fish Diseases·Setu ChakrabortyJavier Santander

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