Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners.

Viruses
Franziska ThomsMartin F Bachmann

Abstract

An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCatTM), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutralizing antibodies against the allergen Fel d 1, which reduces the level of reactive allergen, thus lowering the symptoms or even preventing allergic reactions in humans. The combined methodological field study included ten cat-allergic participants who lived together with their cats (n = 13), that were immunized with Fel-CuMV. The aim was to determine methods for measuring a change in allergic symptoms. A home-based provocation test (petting time and organ specific symptom score (OSSS)) and a general weekly (or monthly) symptom score (G(W)SS) were used to assess changes in allergic symptoms. The petting time until a pre-defined level of allergic symptoms was reached increased already early after vaccination of the cats and was apparent over the course of the study. In addition, the OSSS after provocation and G(W)SS recorded a persistent reduction in symptoms over the study period and could serve for long-term assessment. Hence, the immunization of cats with...Continue Reading

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Citations

Aug 14, 2020·Viruses·Monique Vogel, Martin F Bachmann
Aug 28, 2020·Frontiers in Immunology·Isabella Pali-SchöllErika Jensen-Jarolim
Dec 4, 2020·Nature·Amber Dance
Nov 17, 2020·Allergy, Asthma & Immunology Research·Phornsiri PechsrichuangAlain Jacquet

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT03089788
NCT02399579

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R
Graph Pad Prism
Excel

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