PMID: 9535245Apr 16, 1998Paper

Immunization of children with pertussis toxoid decreases spread of pertussis within the family

The Pediatric Infectious Disease Journal
Birger TrollforsJohn B Robbins

Abstract

In a previously reported double blind placebo-controlled trial it was shown that vaccination with pertussis toxoid during infancy reduced the incidence of pertussis in the vaccinees. Parents and siblings of participants in the trial were followed for pertussis to determine whether vaccination provided indirect protection of close contacts in a nonvaccinating country with a high incidence of pertussis. A group of 3450 infants were randomized to vaccination with diphtheria, tetanus and pertussis toxoids (DTPtxd) or to diphtheria and tetanus toxoids (DT). Pertussis cases were actively sought and diagnosed by cultures and serology in vaccinees (previously reported) and in family members during 2 years after the third vaccination. Pertussis as defined by the World Health Organization (paroxysmal cough of > or = 21 days and certain laboratory criteria) was diagnosed in 11 parents of DTPtxd recipients and in 26 parents of DT recipients; indirect protection was 60% (95% confidence intervals, 16 to 82%). In nonvaccinated younger siblings of DTPtxd and DT recipients there were 10 and 18 cases of pertussis, respectively; indirect protection was 43% (95% confidence intervals, -31 to 76%). When all cases of pertussis with cough > or = 7 day...Continue Reading

References

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Citations

Apr 23, 2003·Vaccine·Marie-Pierre Préziosi, M Elizabeth Halloran
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J TarangerJ B Robbins
Jan 31, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohammad AliJohn Clemens
May 7, 2005·The Pediatric Infectious Disease Journal·Joop SchellekensPierce Gardner
May 7, 2005·The Pediatric Infectious Disease Journal·Aaron M WendelboeJanet A Englund
Jan 15, 2016·Proceedings. Biological Sciences·Matthieu Domenech de CellèsPejman Rohani
Aug 15, 2009·Vaccine·Rose-Marie Carlsson, Birger Trollfors
Jul 18, 2015·Human Vaccines & Immunotherapeutics·Carla D Scarbrough LefebvreBaudouin Standaert
Jan 19, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans O HallanderEva Netterlid
Jul 13, 2004·Vaccine·Eric DesauziersJohannes G Liese
Jul 4, 2012·Vaccine·Mark H RozenbaumMaarten J Postma
Feb 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·John B RobbinsJoseph Shiloach
Nov 25, 2011·Expert Review of Clinical Pharmacology·Hans O HallanderLennart Gustafsson
Oct 13, 2006·Current Opinion in Infectious Diseases·R F BreimanP M McInnes
May 7, 2005·The Pediatric Infectious Disease Journal·Tina Tan
Apr 22, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Madhura S Rane, M Elizabeth Halloran
Dec 10, 1999·Pediatrics·J D Cherry, P Olin

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